Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

Hung Li Wang; Hsin Yeh; Bin Han Li; Chia Her Lin; Ta Chih Hsiao; De Hao Tsai

doi:10.1021/acsanm.9b00834

Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

Hung Li Wang
, Hsin Yeh
, Bin Han Li
, Chia Her Lin
, Ta Chih Hsiao^*
, De Hao Tsai

^*此作品的通信作者

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

44 引文斯高帕斯（Scopus）

摘要

Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH₂ (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH₂). The structural stability of UiO-66-NH₂ versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.

原文	英語
頁（從 - 到）	3329-3334
頁數	6
期刊	ACS Applied Nano Materials
卷	2
發行號	6
DOIs	https://doi.org/10.1021/acsanm.9b00834
出版狀態	已發佈 - 2019 6月 28
對外發佈	是

ASJC Scopus subject areas

一般材料科學

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10.1021/acsanm.9b00834

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title = "Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen",

abstract = "Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.",

keywords = "aerosol, colloid, drug, metal-organic framework, release",

author = "Wang, \{Hung Li\} and Hsin Yeh and Li, \{Bin Han\} and Lin, \{Chia Her\} and Hsiao, \{Ta Chih\} and Tsai, \{De Hao\}",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

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day = "28",

doi = "10.1021/acsanm.9b00834",

language = "English",

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pages = "3329--3334",

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AU - Wang, Hung Li

AU - Yeh, Hsin

AU - Li, Bin Han

AU - Lin, Chia Her

AU - Hsiao, Ta Chih

AU - Tsai, De Hao

PY - 2019/6/28

Y1 - 2019/6/28

N2 - Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.

AB - Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.

KW - aerosol

KW - colloid

KW - drug

KW - metal-organic framework

KW - release

UR - https://www.scopus.com/pages/publications/85068604152

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Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

摘要

ASJC Scopus subject areas

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