Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

Hung Li Wang, Hsin Yeh, Bin Han Li, Chia Her Lin, Ta Chih Hsiao*, De Hao Tsai

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

17 引文 斯高帕斯(Scopus)

摘要

Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.

原文英語
頁(從 - 到)3329-3334
頁數6
期刊ACS Applied Nano Materials
2
發行號6
DOIs
出版狀態已發佈 - 2019 六月 28
對外發佈

ASJC Scopus subject areas

  • 材料科學(全部)

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