Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

Hung Li Wang; Hsin Yeh; Bin Han Li; Chia Her Lin; Ta Chih Hsiao; De Hao Tsai

doi:10.1021/acsanm.9b00834

Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

Hung Li Wang, Hsin Yeh, Bin Han Li, Chia Her Lin, Ta Chih Hsiao^*, De Hao Tsai

^*此作品的通信作者

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

24 引文斯高帕斯（Scopus）

摘要

Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH₂ (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH₂). The structural stability of UiO-66-NH₂ versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.

原文	英語
頁（從 - 到）	3329-3334
頁數	6
期刊	ACS Applied Nano Materials
卷	2
發行號	6
DOIs	https://doi.org/10.1021/acsanm.9b00834
出版狀態	已發佈 - 2019 6月 28
對外發佈	是

ASJC Scopus subject areas

材料科學(全部)

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10.1021/acsanm.9b00834

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title = "Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen",

abstract = "Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.",

keywords = "aerosol, colloid, drug, metal-organic framework, release",

author = "Wang, {Hung Li} and Hsin Yeh and Li, {Bin Han} and Lin, {Chia Her} and Hsiao, {Ta Chih} and Tsai, {De Hao}",

note = "Funding Information: The authors thank the Ministry of Science and Technology of the Republic of China (Taiwan) for financial support under Contract MOST 105-2221-E-007-129-MY3 and MOST 107-2628-E-007-002-MY3. The authors also thank Prof. Hsing-Wen Sung at NTHU for support of the experiments. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

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doi = "10.1021/acsanm.9b00834",

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AU - Wang, Hung Li

AU - Yeh, Hsin

AU - Li, Bin Han

AU - Lin, Chia Her

AU - Hsiao, Ta Chih

AU - Tsai, De Hao

N1 - Funding Information: The authors thank the Ministry of Science and Technology of the Republic of China (Taiwan) for financial support under Contract MOST 105-2221-E-007-129-MY3 and MOST 107-2628-E-007-002-MY3. The authors also thank Prof. Hsing-Wen Sung at NTHU for support of the experiments. Publisher Copyright: © 2019 American Chemical Society.

PY - 2019/6/28

Y1 - 2019/6/28

N2 - Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.

AB - Electrospray-differential mobility analysis coupled with aerosol particle mass analysis (ES-DMA/APM) was demonstrated for the development of a metal-organic framework (MOF) nanocarrier system. A successful quantification of ibuprofen loading in UiO-66-NH2 (i.e., the representative drug molecule and MOF, respectively) achieved based on the aerosol particle mass of MOF measured by ES-DMA/APM (≈55 mg of ibuprofen/g of UiO-66-NH2). The structural stability of UiO-66-NH2 versus ibuprofen release was successfully quantified over a 7-day period in an acidic phosphate buffer solution. The methodology provides a proof-of-concept scheme for controlled release studies of different types of active pharmaceutical ingredients from a variety of MOF-based nanocarrier systems.

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Zirconium-Based Metal-Organic Framework Nanocarrier for the Controlled Release of Ibuprofen

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