Zerumbet Ginger Extract Attenuates Chemotherapy-Induced Toxicity and Promotes Tumor Suppression in a Murine Breast Cancer Model

Li Yu Su; Liang Chuan Lai; Chi Feng Cheng; Chia Ying Lien; Ming Chung Lee; Wu Chang Chuang; Chung Hsin Wu

doi:10.1002/fsn3.71273

Zerumbet Ginger Extract Attenuates Chemotherapy-Induced Toxicity and Promotes Tumor Suppression in a Murine Breast Cancer Model

Li Yu Su
, Liang Chuan Lai^*
, Chi Feng Cheng
, Chia Ying Lien
, Ming Chung Lee
, Wu Chang Chuang
, Chung Hsin Wu^*

^*此作品的通信作者

生命科學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

1 引文斯高帕斯（Scopus）

摘要

Zerumbet ginger extract (ZGE) shows strong anticancer potential and enhances doxorubicin (DOX) efficacy against breast cancer while reducing its systemic toxicity. GC–MS identified zerumbone as a key bioactive. ZGE inhibited 4 T1 cell growth and tumor progression in mice and improved antioxidant activity. Combined ZGE + DOX treatment boosted antitumor effects and alleviated DOX-induced cardiotoxicity, hepatotoxicity, and nephrotoxicity, as reflected in biochemical markers. Mechanistically, ZGE suppressed TRPM2 and calcium signaling, promoting ROS-mediated apoptosis. These findings support ZGE as a promising adjuvant in breast cancer therapy.

原文	英語
文章編號	e71273
期刊	Food Science and Nutrition
卷	13
發行號	12
DOIs	https://doi.org/10.1002/fsn3.71273
出版狀態	已發佈 - 2025 12月

UN SDG

此研究成果有助於以下永續發展目標

SDG 3 健康與福祉

ASJC Scopus subject areas

食品科學

存取文件

10.1002/fsn3.71273

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Link to publication in Scopus

引用此

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title = "Zerumbet Ginger Extract Attenuates Chemotherapy-Induced Toxicity and Promotes Tumor Suppression in a Murine Breast Cancer Model",

abstract = "Zerumbet ginger extract (ZGE) shows strong anticancer potential and enhances doxorubicin (DOX) efficacy against breast cancer while reducing its systemic toxicity. GC–MS identified zerumbone as a key bioactive. ZGE inhibited 4 T1 cell growth and tumor progression in mice and improved antioxidant activity. Combined ZGE + DOX treatment boosted antitumor effects and alleviated DOX-induced cardiotoxicity, hepatotoxicity, and nephrotoxicity, as reflected in biochemical markers. Mechanistically, ZGE suppressed TRPM2 and calcium signaling, promoting ROS-mediated apoptosis. These findings support ZGE as a promising adjuvant in breast cancer therapy.",

keywords = "TRPM2 channel, antioxidant activity, breast cancer, chemotherapy, doxorubicin, zerumbet ginger extract",

author = "Su, \{Li Yu\} and Lai, \{Liang Chuan\} and Cheng, \{Chi Feng\} and Lien, \{Chia Ying\} and Lee, \{Ming Chung\} and Chuang, \{Wu Chang\} and Wu, \{Chung Hsin\}",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Food Science \& Nutrition published by Wiley Periodicals LLC.",

year = "2025",

month = dec,

doi = "10.1002/fsn3.71273",

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journal = "Food Science and Nutrition",

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TY - JOUR

T1 - Zerumbet Ginger Extract Attenuates Chemotherapy-Induced Toxicity and Promotes Tumor Suppression in a Murine Breast Cancer Model

AU - Su, Li Yu

AU - Lai, Liang Chuan

AU - Cheng, Chi Feng

AU - Lien, Chia Ying

AU - Lee, Ming Chung

AU - Chuang, Wu Chang

AU - Wu, Chung Hsin

PY - 2025/12

Y1 - 2025/12

N2 - Zerumbet ginger extract (ZGE) shows strong anticancer potential and enhances doxorubicin (DOX) efficacy against breast cancer while reducing its systemic toxicity. GC–MS identified zerumbone as a key bioactive. ZGE inhibited 4 T1 cell growth and tumor progression in mice and improved antioxidant activity. Combined ZGE + DOX treatment boosted antitumor effects and alleviated DOX-induced cardiotoxicity, hepatotoxicity, and nephrotoxicity, as reflected in biochemical markers. Mechanistically, ZGE suppressed TRPM2 and calcium signaling, promoting ROS-mediated apoptosis. These findings support ZGE as a promising adjuvant in breast cancer therapy.

AB - Zerumbet ginger extract (ZGE) shows strong anticancer potential and enhances doxorubicin (DOX) efficacy against breast cancer while reducing its systemic toxicity. GC–MS identified zerumbone as a key bioactive. ZGE inhibited 4 T1 cell growth and tumor progression in mice and improved antioxidant activity. Combined ZGE + DOX treatment boosted antitumor effects and alleviated DOX-induced cardiotoxicity, hepatotoxicity, and nephrotoxicity, as reflected in biochemical markers. Mechanistically, ZGE suppressed TRPM2 and calcium signaling, promoting ROS-mediated apoptosis. These findings support ZGE as a promising adjuvant in breast cancer therapy.

KW - TRPM2 channel

KW - antioxidant activity

KW - breast cancer

KW - chemotherapy

KW - doxorubicin

KW - zerumbet ginger extract

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UR - https://www.scopus.com/pages/publications/105022852288#tab=citedBy

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DO - 10.1002/fsn3.71273

M3 - Article

AN - SCOPUS:105022852288

SN - 2048-7177

VL - 13

JO - Food Science and Nutrition

JF - Food Science and Nutrition

IS - 12

M1 - e71273

ER -

Zerumbet Ginger Extract Attenuates Chemotherapy-Induced Toxicity and Promotes Tumor Suppression in a Murine Breast Cancer Model

摘要

UN SDG

ASJC Scopus subject areas

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