Within-Host Viral Dynamics in a Multi-compartmental Environment

Shyan Shiou Chen, Chang Yuan Cheng, Libin Rong

研究成果: 雜誌貢獻期刊論文同行評審

摘要

The discrepancy in the turnover of cells and virus in different organs or viral reservoirs necessitates the investigation of multiple compartments within a host. Establishing a multi-compartmental structure that describes the complexity of various organs, where viral infection comprehensively proceeds, provides a modeling framework for exploring the effect of spatial heterogeneity on viral dynamics. To successfully suppress within-host viral replication, it is imperative to determine drug administration during therapy, particularly for a combination of antiretroviral drugs. The proposed model provides quantitative insights into pharmacokinetics and the resulting virus population, which substantially relates to environmental heterogeneity. The main results are the following: (1) A model incorporating drug treatment admits threshold dynamics, driving to either viral extinction or uniform persistence, regardless of non-trivial initial infection, in the entire system. (2) Viral infection may be underestimated if a well-mixed (single-compartmental) model is used. (3) Optimal drug administration depends not only on the drug distribution over various compartments but also on the timing, described by phase shifts, of the administration of different drugs in a combined therapy.

原文英語
頁(從 - 到)4271-4308
頁數38
期刊Bulletin of Mathematical Biology
81
發行號10
DOIs
出版狀態已發佈 - 2019 十月 1

ASJC Scopus subject areas

  • 神經科學 (全部)
  • 免疫學
  • 數學(全部)
  • 生物化學、遺傳與分子生物學 (全部)
  • 環境科學 (全部)
  • 藥理
  • 農業與生物科學 (全部)
  • 計算機理論與數學

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