Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction

Chin Yih Hong; W. S. Chen; Z. F. Jian; S. Y. Yang; H. E. Horng; L. C. Yang; H. C. Yang

doi:10.1063/1.2536127

Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction

Chin Yih Hong, W. S. Chen, Z. F. Jian, S. Y. Yang, H. E. Horng^*, L. C. Yang, H. C. Yang

^*此作品的通信作者

光電工程學士學位學程

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

45 引文斯高帕斯（Scopus）

摘要

In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility ac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for ac -reduction immunomagnetic detection.

原文	英語
文章編號	074105
期刊	Applied Physics Letters
卷	90
發行號	7
DOIs	https://doi.org/10.1063/1.2536127
出版狀態	已發佈 - 2007

ASJC Scopus subject areas

物理與天文學（雜項）

存取文件

10.1063/1.2536127

其它文件與鏈接

引用此

@article{83b2260c8f014b719a40ac6591b01c19,

title = "Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction",

abstract = "In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility ac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for ac -reduction immunomagnetic detection.",

author = "Hong, {Chin Yih} and Chen, {W. S.} and Jian, {Z. F.} and Yang, {S. Y.} and Horng, {H. E.} and Yang, {L. C.} and Yang, {H. C.}",

year = "2007",

doi = "10.1063/1.2536127",

language = "English",

volume = "90",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics Publising LLC",

number = "7",

}

TY - JOUR

T1 - Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction

AU - Hong, Chin Yih

AU - Chen, W. S.

AU - Jian, Z. F.

AU - Yang, S. Y.

AU - Horng, H. E.

AU - Yang, L. C.

AU - Yang, H. C.

PY - 2007

Y1 - 2007

N2 - In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility ac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for ac -reduction immunomagnetic detection.

AB - In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility ac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for ac -reduction immunomagnetic detection.

UR - http://www.scopus.com/inward/record.url?scp=33847158802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847158802&partnerID=8YFLogxK

U2 - 10.1063/1.2536127

DO - 10.1063/1.2536127

M3 - Article

AN - SCOPUS:33847158802

SN - 0003-6951

VL - 90

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 7

M1 - 074105

ER -

Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

引用此