Wash-free immunomagnetic detection for serum through magnetic susceptibility reduction

Chin Yih Hong, W. S. Chen, Z. F. Jian, S. Y. Yang, H. E. Horng, L. C. Yang, H. C. Yang

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    41 引文 斯高帕斯(Scopus)

    摘要

    In this study, a platform for wash-free immunomagnetic detections is discussed. The reagent is a magnetic fluid composed of biofunctionalized magnetic particles dispersed in water. The assay instrument is a mixed-frequency magnetosusceptometer. The mixed-frequency ac magnetic susceptibility ac of the magnetic reagent is reduced, as a result of the formation of magnetic clusters via the association among magnetic nanoparticles and a specific biotarget. The immunoassay detection of proteins in water, such as aqueous c-reactive protein, is characterized and is compared to that in serum. These observations demonstrate the advantages of high convenience, high sensitivity, and high specificity for ac -reduction immunomagnetic detection.

    原文英語
    文章編號074105
    期刊Applied Physics Letters
    90
    發行號7
    DOIs
    出版狀態已發佈 - 2007

    ASJC Scopus subject areas

    • Physics and Astronomy (miscellaneous)

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