Vescalagin from pink wax apple (Syzygium samarangense (blume) merrill and perry) protects pancreatic β-cells against methylglyoxal-induced inflammation in rats

Wen Chang Chang, James Swi Bea Wu, Szu Chuan Shen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

1 引文 斯高帕斯(Scopus)

摘要

Methylglyoxal (MG) is the primary precursor of advanced glycation end products involved in the pathogenesis of inflammation and diabetes. A previous study in our laboratory found anti-inflammatory and anti-hyperglycemic effects of the polyphenol vescalagin (VES) in rats with MG-induced carbohydrate metabolic disorder. The present study further investigated the occurrence of inflammation in pancreatic β-cells in MG-induced diabetic rats and the mechanism by which VES prevents it. The results showed that VES downregulates the protein expression levels of advanced glycation end product receptors and CCAAT/enhancer binding protein-β and upregulates the protein expression levels of pancreatic duodenal homeobox-1, nuclear factor erythroid 2-related factor 2 and glyoxalase I from the pancreatic cells. The results also revealed that VES elevates glutathione and antioxidant enzyme contents and then downregulates c-Jun N-terminal kinase and p38 mitogen-activated protein kinases pathways to protect pancreatic β-cells in MG-administered rats.

原文英語
文章編號1448
期刊Plants
10
發行號7
DOIs
出版狀態已發佈 - 2021 7月

ASJC Scopus subject areas

  • 生態學、進化論、行為學與系統學
  • 生態學
  • 植物科學

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