Use of a high-Tc SQUID-based nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate tumors in rats, by characterizing the longitudinal relaxation rate

K. W. Huang, H. H. Chen, H. C. Yang*, H. E. Horng, S. H. Liao, J. J. Chieh, Y. Yang

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

6 引文 斯高帕斯(Scopus)

摘要

This study uses a sensitive, high-Tc SQUID-detected nuclear magnetic resonance spectrometer in magnetically unshielded environments to discriminate liver tumors in rats, by characterizing the longitudinal relaxation rate, T1-1. The high-Tc SQUID-based spectrometer has a spectral line width of 0.9Hz in low magnetic fields. It was found that relaxation rate for tumor tissues is (3.6 ± 0.02) s -1 and the relaxation rate for normal tissues is (7.7 ± 0.02) s-1. The difference in the longitudinal relaxation rates suggests that water structures around the DNA of cancer cells are different from those of normal tissues. The optimized detection sensitivity for the established system is 0.21 g at the present stage. It is concluded that T1-1 can be used to distinguish cancerous tissues from normal tissues. The high-Tc, SQUID-detected NMR and MRI in magnetically unshielded environments may also be useful for discriminating other tumors.

原文英語
文章編號P06005
期刊Journal of Instrumentation
7
發行號6
DOIs
出版狀態已發佈 - 2012 6月

ASJC Scopus subject areas

  • 數學物理學
  • 儀器

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