Urinary phenols and parabens in relation to hearing loss: The National Health and Nutrition Examination Survey

Ming Chieh Li*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

Introduction: The animal studies raise concerns about the possible ototoxicity of phenolic chemicals. Therefore, we conducted an epidemiologic study to examine the associations of phenols and parabens with hearing impairment. Materials and methods: Bisphenol A (BPA), benzophenone-3 (BP-3), and triclosan (TCS) were measured in urine samples in the National Health and Nutrition Examination Survey (NHANES) 2003–06 and 2009–12. Methyl paraben (MPB) and propyl paraben (PPB) were measured in urine samples in NHANES 2005–06 and 2009–12. Hearing impairment was defined as a hearing threshold of more than 25 dB at each hearing frequency in the better ear. Tests for linear trend were conducted using the median concentrations of urinary phenols or parabens in each quartile as a continuous variable. Results: A total of 1809 participants (women = 52.0%) aged 20 and above were included in the final analysis (For MPB and PPB, the sample size was 1188). After adjusting for potential confounders, we found positive associations between BPA and hearing impairment at 3 K (p-trend = 0.04); between TCS and hearing impairment at 6 K (p-trend = 0.03); However, the odds ratio (OR) for the highest compared with the lowest quartile of both BPA and TCS did not reach statistical significance. In contrast, we found unexpected negative associations between BP-3 and hearing impairment at 0.5 K (p-trend = 0.04), 1 K (p-trend = 0.02), 2 K (p-trend <0.01), 6 K (p-trend = 0.03), and 8 K Hz (p-trend = 0.02), respectively. Conclusions: The present study offers limited evidence that background phenol and paraben exposures are ototoxicants for the United States adult population.

原文英語
頁(從 - 到)331-335
頁數5
期刊Journal of Environmental Health Science and Engineering
20
發行號1
DOIs
出版狀態已發佈 - 2022 6月

ASJC Scopus subject areas

  • 環境工程
  • 應用微生物與生物技術
  • 水科學與技術
  • 廢物管理和處置
  • 污染
  • 公共衛生、環境和職業健康
  • 健康、毒理學和誘變

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