摘要
Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD). We conducted a case-control study in a cohort of 369 PD cases and another cohort of 326 ethnically matched controls to investigate the association of tumor necrosis factor-α (TNF-α) promoter single nucleotide polymorphisms (SNPs) with the risk of PD. The overall genotype distribution at T-1031C and C-857T sites showed significant difference between PD cases and controls (P = 0.0082 and 0.0035, respectively). However, only the more frequent -1031 CC genotype was evidently associated with PD (P = 0.0085, odds ratio: 2.98; 95% CI: 1.38-7.09). Pairwise SNP linkage disequilibrium showed -1031 and -863 sites are in strong linkage disequilibrium (D′ = 0.93, Δ2 = 0.80). Pairwise haplotype analysis among the four sites showed that -1031C-863A may act as a risk haplotype among PD cases (P = 0.0028, odds ratio: 2.18; 95% CI: 1.33-3.69).
原文 | 英語 |
---|---|
頁(從 - 到) | 300-304 |
頁數 | 5 |
期刊 | American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics |
卷 | 144 |
發行號 | 3 |
DOIs | |
出版狀態 | 已發佈 - 2007 4月 5 |
ASJC Scopus subject areas
- 遺傳學(臨床)
- 精神病學和心理健康
- 細胞與分子神經科學