Transition-metal-free carbofluorination of TBS-protected nitrogen-containing cyclic enynols: Synthesis of fluorinated azabicycles

Ming Chang P. Yeh*, Chia Jung Liang, Tzu Lin Huang, Hsiao Ju Hsu, Yu Shuo Tsau

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

29 引文 斯高帕斯(Scopus)

摘要

The synthesis of fluorinated azabicycles from tert-butyldimethylsilyl- protected N-containing cyclic enynols using inexpensive BF3· OEt2 is described. In this reaction, BF3 reacts as both the Lewis acid and the fluoride source for cyclization/fluorination of the TBS-protected cyclic N-containing enynols. The method provides an easy access to fluorinated azabicycles where a new C(sp2)-F bond and a new bicyclic skeleton are generated at ambient temperature within 1-13 min under metal-free reaction conditions.

原文英語
頁(從 - 到)5521-5529
頁數9
期刊Journal of Organic Chemistry
78
發行號11
DOIs
出版狀態已發佈 - 2013 6月 7

ASJC Scopus subject areas

  • 有機化學

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