@article{26e643c6544b4e3ca6b5aa1a4df1afff,
title = "Total synthesis of pseudouridine: Via Heck-type C-glycosylation",
abstract = "The reaction of 2,4-dimethoxy-5-iodopyrimidine (8) and 3,5-di-O-tert-butyldimethylsilyl protected ribofuranoid glycal 4 was carried out with Pd(OAc)2 as the catalyst, PPh3 as the ligand and Et3N as the base in DMF at 70 °C followed by desilylation to afford exclusively the β-anomer of 5-(2,3-dideoxy-3-oxoribofuranosyl)-2,4-dimethoxypyrimidine (11) in a very good yield. The subsequent protecting group and functional group interconversions furnished pseudouridine (Ψ, 1).",
author = "Yu, {Cheng Ping} and Chang, {Hsin Yun} and Chien, {Tun Cheng}",
note = "Funding Information: This work was supported by the National Taiwan Normal University and the Research Grants MOST 107-2113-M-003-002- A nd MOST 106-2113-M-003-006-from the Ministry of Science and Technology, Taiwan. Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.",
year = "2019",
doi = "10.1039/c9nj01012b",
language = "English",
volume = "43",
pages = "8796--8803",
journal = "New Journal of Chemistry",
issn = "1144-0546",
publisher = "Royal Society of Chemistry",
number = "22",
}