Total synthesis of pseudouridine: Via Heck-type C-glycosylation

Cheng Ping Yu, Hsin Yun Chang, Tun Cheng Chien*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

1 引文 斯高帕斯(Scopus)

摘要

The reaction of 2,4-dimethoxy-5-iodopyrimidine (8) and 3,5-di-O-tert-butyldimethylsilyl protected ribofuranoid glycal 4 was carried out with Pd(OAc)2 as the catalyst, PPh3 as the ligand and Et3N as the base in DMF at 70 °C followed by desilylation to afford exclusively the β-anomer of 5-(2,3-dideoxy-3-oxoribofuranosyl)-2,4-dimethoxypyrimidine (11) in a very good yield. The subsequent protecting group and functional group interconversions furnished pseudouridine (Ψ, 1).

原文英語
頁(從 - 到)8796-8803
頁數8
期刊New Journal of Chemistry
43
發行號22
DOIs
出版狀態已發佈 - 2019 一月 1

ASJC Scopus subject areas

  • 催化
  • 化學 (全部)
  • 材料化學

指紋

深入研究「Total synthesis of pseudouridine: Via Heck-type C-glycosylation」主題。共同形成了獨特的指紋。

引用此