To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an FeIII-Porphyrin Center

Yu Ting Tseng; Chien Hong Chen; Jing Yu Lin; Bing Han Li; Yu Huan Lu; Chia Her Lin; Hsin Tsung Chen; Tsu Chien Weng; Dimosthenes Sokaras; Huang Yeh Chen; Yun Liang Soo; Tsai Te Lu

doi:10.1002/chem.201503176

To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an Fe^III-Porphyrin Center

Yu Ting Tseng
, Chien Hong Chen
, Jing Yu Lin
, Bing Han Li
, Yu Huan Lu
, Chia Her Lin
, Hsin Tsung Chen
, Tsu Chien Weng
, Dimosthenes Sokaras
, Huang Yeh Chen
, Yun Liang Soo
, Tsai Te Lu^*

^*此作品的通信作者

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

26 引文斯高帕斯（Scopus）

摘要

A positive myocardial inotropic effect achieved using HNO/NO^-, compared with NO· triggered attempts to explore novel nitroxyl donors for use in clinical applications in vascular and myocardial pharmacology. To develop M-NO complexes for nitroxyl chemistry and biology, modulation of direct nitroxyl-transfer reactivity of dinitrosyl iron complexes (DNICs) is investigated in this study using a Fe^III-porphyrin complex and proteins as a specific probe. Stable dinuclear {Fe(NO)₂}⁹ DNIC [Fe(μ-^MePyr)(NO)₂]₂ was discovered as a potent nitroxyl donor for nitroxylation of Fe^III-heme centers through an associative mechanism. Beyond the efficient nitroxyl transfer, transformation of DNICs into a chemical biology probe for nitroxyl and for pharmaceutical applications demands further efforts using in vitro/in vivo studies. A dinitrosyl iron complex, DNIC [Fe(μ-^MePyr)(NO)₂]₂, was found to be a potent nitroxyl donor for prospective clinical applications in vascular and myocardial pharmacology.

原文	英語
頁（從 - 到）	17570-17573
頁數	4
期刊	Chemistry - A European Journal
卷	21
發行號	49
DOIs	https://doi.org/10.1002/chem.201503176
出版狀態	已發佈 - 2015 12月 1
對外發佈	是

ASJC Scopus subject areas

催化
一般化學
有機化學

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10.1002/chem.201503176

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引用此

Tseng, Y. T., Chen, C. H., Lin, J. Y., Li, B. H., Lu, Y. H., Lin, C. H., Chen, H. T., Weng, T. C., Sokaras, D., Chen, H. Y., Soo, Y. L., & Lu, T. T. (2015). To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an Fe^III-Porphyrin Center. Chemistry - A European Journal, 21(49), 17570-17573. https://doi.org/10.1002/chem.201503176

Tseng, YT, Chen, CH, Lin, JY, Li, BH, Lu, YH, Lin, CH, Chen, HT, Weng, TC, Sokaras, D, Chen, HY, Soo, YL & Lu, TT 2015, 'To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an Fe^III-Porphyrin Center', Chemistry - A European Journal, 卷 21, 編號 49, 頁 17570-17573. https://doi.org/10.1002/chem.201503176

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abstract = "A positive myocardial inotropic effect achieved using HNO/NO-, compared with NO· triggered attempts to explore novel nitroxyl donors for use in clinical applications in vascular and myocardial pharmacology. To develop M-NO complexes for nitroxyl chemistry and biology, modulation of direct nitroxyl-transfer reactivity of dinitrosyl iron complexes (DNICs) is investigated in this study using a FeIII-porphyrin complex and proteins as a specific probe. Stable dinuclear \{Fe(NO)2\}9 DNIC [Fe(μ-MePyr)(NO)2]2 was discovered as a potent nitroxyl donor for nitroxylation of FeIII-heme centers through an associative mechanism. Beyond the efficient nitroxyl transfer, transformation of DNICs into a chemical biology probe for nitroxyl and for pharmaceutical applications demands further efforts using in vitro/in vivo studies. A dinitrosyl iron complex, DNIC [Fe(μ-MePyr)(NO)2]2, was found to be a potent nitroxyl donor for prospective clinical applications in vascular and myocardial pharmacology.",

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doi = "10.1002/chem.201503176",

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AU - Li, Bing Han

AU - Lu, Yu Huan

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AU - Weng, Tsu Chien

AU - Sokaras, Dimosthenes

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AU - Soo, Yun Liang

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AB - A positive myocardial inotropic effect achieved using HNO/NO-, compared with NO· triggered attempts to explore novel nitroxyl donors for use in clinical applications in vascular and myocardial pharmacology. To develop M-NO complexes for nitroxyl chemistry and biology, modulation of direct nitroxyl-transfer reactivity of dinitrosyl iron complexes (DNICs) is investigated in this study using a FeIII-porphyrin complex and proteins as a specific probe. Stable dinuclear {Fe(NO)2}9 DNIC [Fe(μ-MePyr)(NO)2]2 was discovered as a potent nitroxyl donor for nitroxylation of FeIII-heme centers through an associative mechanism. Beyond the efficient nitroxyl transfer, transformation of DNICs into a chemical biology probe for nitroxyl and for pharmaceutical applications demands further efforts using in vitro/in vivo studies. A dinitrosyl iron complex, DNIC [Fe(μ-MePyr)(NO)2]2, was found to be a potent nitroxyl donor for prospective clinical applications in vascular and myocardial pharmacology.

KW - X-ray emission spectroscopy

KW - bioinorganic chemistry

KW - nitrosyl complexes

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To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an FeIII-Porphyrin Center

摘要

ASJC Scopus subject areas

存取文件

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引用此

To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an Fe^III-Porphyrin Center