To Transfer or Not to Transfer? Development of a Dinitrosyl Iron Complex as a Nitroxyl Donor for the Nitroxylation of an FeIII-Porphyrin Center

Yu Ting Tseng, Chien Hong Chen, Jing Yu Lin, Bing Han Li, Yu Huan Lu, Chia Her Lin, Hsin Tsung Chen, Tsu Chien Weng, Dimosthenes Sokaras, Huang Yeh Chen, Yun Liang Soo, Tsai Te Lu*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

20 引文 斯高帕斯(Scopus)

摘要

A positive myocardial inotropic effect achieved using HNO/NO-, compared with NO· triggered attempts to explore novel nitroxyl donors for use in clinical applications in vascular and myocardial pharmacology. To develop M-NO complexes for nitroxyl chemistry and biology, modulation of direct nitroxyl-transfer reactivity of dinitrosyl iron complexes (DNICs) is investigated in this study using a FeIII-porphyrin complex and proteins as a specific probe. Stable dinuclear {Fe(NO)2}9 DNIC [Fe(μ-MePyr)(NO)2]2 was discovered as a potent nitroxyl donor for nitroxylation of FeIII-heme centers through an associative mechanism. Beyond the efficient nitroxyl transfer, transformation of DNICs into a chemical biology probe for nitroxyl and for pharmaceutical applications demands further efforts using in vitro/in vivo studies. A dinitrosyl iron complex, DNIC [Fe(μ-MePyr)(NO)2]2, was found to be a potent nitroxyl donor for prospective clinical applications in vascular and myocardial pharmacology.

原文英語
頁(從 - 到)17570-17573
頁數4
期刊Chemistry - A European Journal
21
發行號49
DOIs
出版狀態已發佈 - 2015 十二月 1
對外發佈

ASJC Scopus subject areas

  • 催化
  • 有機化學

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