The organocatalytic asymmetric synthesis of hexahydropyridazines were performed through a unique Michael/amination/cyclization reaction. The organocascade reaction proceeded smoothly between 2-arylidene-1,3-indandiones and aldehydes followed by the addition of azodicarboxylates catalyzed by the privileged organocatalyst α,-α-L-diphenylprolinol trimethylsilyl ether (10 mol%) in the presence of a base additive Et3N (20 mo%) at 0 C. A series of substituted hexahydropyridazines were obtained in good to high chemical yields (55-78 %) and reasonable to high levels of stereoselectivities (51-93 % ee and 4 : 1 d.r.).
|頁（從 - 到）||843-849|
|期刊||Journal of the Chinese Chemical Society|
|出版狀態||已發佈 - 2015 10月 1|
ASJC Scopus subject areas
- 化學 (全部)