The recycling of L-citrulline to L-arginine in a chicken macrophage cell line

C. L. Su, R. E. Austic*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

9 引文 斯高帕斯(Scopus)

摘要

L-Arginine is the only biological substrate of nitric oxide synthase in a reaction yielding NO and L-citrulline as co-products. The resynthesis of L-arginine from L-citrulline has been observed in murine macrophages. However, it is not known whether avian macrophages have a similar capacity for the synthesis of arginine. The present studies were carried out to determine whether L-citrulline can support NO (measured as nitrite) production in the HD11 cell, a chicken macrophage cell line. When added to media lacking L-arginine, L-citrulline supported a low level of nitrite accumulation: about 4 to 11% of the amount of nitrite formed from an equivalent concentration of L-arginine. Aspartic acid was not limiting for NO production from citrulline.

原文英語
頁(從 - 到)353-355
頁數3
期刊Poultry science
78
發行號3
DOIs
出版狀態已發佈 - 1999 三月

ASJC Scopus subject areas

  • 動物科學與動物學

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