摘要
The highly functionalized organometallics RCu(CN)ZnI 1 react efficiently with 1-haloalkynes providing polyfunctionalized alkynes in high yields. This method has been used to prepare a pheromone of the Amathes c-nigrum in 3 steps and 64% overall yield. The reagents 1 also add in the presence of an excess of Me3SiCl to acetylenic esters to afford polyfunctionalized C-silylated ethylenic esters. In the case of ethyl propiolate, the reaction is highly stereoselective and affords 97% pure (E)-2-trimethylsilyl ethylenic esters.
原文 | 英語 |
---|---|
頁(從 - 到) | 4799-4802 |
頁數 | 4 |
期刊 | Tetrahedron Letters |
卷 | 30 |
發行號 | 36 |
DOIs | |
出版狀態 | 已發佈 - 1989 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 生物化學
- 藥物發現
- 有機化學