The reactivity of the highly functionalized copper, zinc reagents RCu(CN)ZnI toward 1-haloalkynes and acetylenic esters

Ming Chang P. Yeh*, Paul Knochel

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

111 引文 斯高帕斯(Scopus)

摘要

The highly functionalized organometallics RCu(CN)ZnI 1 react efficiently with 1-haloalkynes providing polyfunctionalized alkynes in high yields. This method has been used to prepare a pheromone of the Amathes c-nigrum in 3 steps and 64% overall yield. The reagents 1 also add in the presence of an excess of Me3SiCl to acetylenic esters to afford polyfunctionalized C-silylated ethylenic esters. In the case of ethyl propiolate, the reaction is highly stereoselective and affords 97% pure (E)-2-trimethylsilyl ethylenic esters.

原文英語
頁(從 - 到)4799-4802
頁數4
期刊Tetrahedron Letters
30
發行號36
DOIs
出版狀態已發佈 - 1989
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 藥物發現
  • 有機化學

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