摘要
The 1,4-addition of various thiols to α,β-unsaturated ketones was completed rapidly in the presence of a catalytic amount (2-3 mol %) of anhydrous iron(III) chloride under solvent free conditions and an air atmosphere. Anhydrous iron(III) chloride is more active than that of other ferric salts. With more reactive and/or less steric reagents (1a-c and/or 2a-2c), expeditious conditions (short reaction times at room temperature) could be employed. With less reactive and/or steric reagents (1d-g and/or 2d-e), a slight increase in reaction time was required, but high yields were obtained. The FeCl3 catalyst causes preferential interactions with α,β-unsaturated ketones present in the reaction.
原文 | 英語 |
---|---|
頁(從 - 到) | 7375-7380 |
頁數 | 6 |
期刊 | Tetrahedron Letters |
卷 | 47 |
發行號 | 41 |
DOIs | |
出版狀態 | 已發佈 - 2006 十月 9 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry