The interaction between acute oligomer Aβ1-40 and stress severely impaired spatial learning and memory

Hei Jen Huang, Keng Chen Liang, Yen Yu Chang, Hsing Chieh Ke, Jia Yu Lin, Hsiu Mei Hsieh

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

摘要

In this study, we investigated whether stress can enhance the toxicity of oligomer Aβ1-40 in the mouse brain. Stress was applied to the animals, consisting of a 2-day inescapable foot shock followed by 3-weekly situation reminders (SRs). We found that stress significantly affected not only the amygdala-dependent (anxiety) but also the hippocampal-dependent (spatial learning and memory) behaviors through the oxidative damage caused in these two regions. However, oligomer Aβ1-40 treatment alone did not induce behavioral impairment. In addition, combined oligomer Aβ1-40 and stress treatment increased the glucocorticoid receptor (GR)/mineralocorticoid receptor (MR) ratio and the expression of corticotrophin releasing factor 1 (CRF-1) receptor in the hippocampus. Changes in the components of the hypothalamic-pituitary-adrenal (HPA) axis, such as the GR/MR ratio and CRF-1 level, were observed, accompanied by increasing Aβ accumulation, oxidative stress, nuclear transcription factor (NF-κB) hypoactivity, and apoptotic signaling in the hippocampus, and decreasing calbindin D28K and NMDA receptor 2A/2B (NR2A/2B) in the hippocampus, along with alteration of the cholinergic neurons (ChAT) in the medium septum/diagnoid band (MS/DB), noradrenergic neurons (TH) in the locus coeruleus (LC), and serotonergic neurons (5-HT) in the Raphe nucleus. Therefore, apoptosis and synaptic dysfunction in the hippocampus severely induced the impairment of spatial learning and memory. These results suggest that stress may play an important role in the early stages of Alzheimer's disease (AD), and an antioxidant strategy might be a potential therapeutic approach for stress-mediated disorders.

原文英語
頁(從 - 到)8-18
頁數11
期刊Neurobiology of Learning and Memory
93
發行號1
DOIs
出版狀態已發佈 - 2010 一月 1

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

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