The Influence of type 2 diabetes and glucose-lowering therapies on cancer risk in the Taiwanese

Ming Chia Hsieh, Tzu Chi Lee, Shu Min Cheng, Shih Te Tu, Ming Hong Yen, Chin Hsiao Tseng*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

130 引文 斯高帕斯(Scopus)

摘要

Objective. To investigate the association between type 2 diabetes, glucose-lowering therapies (monotherapy with either metformin, sulphonylurea or insulin) and cancer risk in Taiwan. Methods. Using Taiwans National Health Research Institutes database of 1,000,000 random subjects from 20002008, we found 61777 patients with type 2 diabetes (age 20 years) and 677378 enrollees with no record of diabetes. Results. After adjusting for age and sex, we found patients with diabetes to have significantly higher risk of all cancers (OR: 1.176; 95% CI: 1.1491.204, P 0.001). Diabetic patients treated with insulin or sulfonylureas had significantly higher risk of all cancers, compared to those treated with metformin (OR: 1.583; 95% CI: 1.3891.805, P 0.001 and OR: 1.784; 95% CI: 1.4062.262, P 0.001). Metformin treatment was associated with a decreased risk of colon and liver cancer compared to sulphonylureas or insulin treatment. Sulfonylureas treatment was associated with an increased risk of breast and lung cancer compared to metformin therapy. Conclusions. Taiwanese with type 2 diabetes are at a high risk of breast, prostate, colon, lung, liver and pancreatic cancer. Those treated with insulin or sulfonylureas monotherapy are more likely to develop colon and liver cancer than those treated with metformin.

原文英語
文章編號413782
期刊Experimental Diabetes Research
2012
DOIs
出版狀態已發佈 - 2012
對外發佈

ASJC Scopus subject areas

  • 內分泌學、糖尿病和代謝

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