The effect of covalent immobilization of sialic acid on the removal of lipopolysaccharide and reactive oxygen species for polyethylene terephthalate

Jung Jhih Chang, Po Ju Lin, Yen Hsien Lee, Ming Chien Yang, Chiang-Ting Chien

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

Polyethylene terephthalate (PET) was aminolyzed with 1,6-diaminohexane (DAH) and then sialic acid (NANA) was immobilized via amidation onto the surface. The surface concentration of NANA was determined by 2-thiobarbituric acid (TBA) test. The hemocompatibility of the resulting PET fabrics was evaluated based on complete blood count (CBC), coagulating times, and protein adsorption. The ability to remove lipopolysaccharide (LPS) was also determined. In addition, the effect of contacting NANA-immobilizing PET on the suppression of reactive oxygen species (ROS) production was measured by the chemiluminescence (CL) method. The results show that by immobilizing NANA onto PET, the adhesion of platelet (PLt) was reduced, and oxidative stress was suppressed. The level of LPS was also greatly reduced.

原文英語
頁(從 - 到)1872-1878
頁數7
期刊Polymers for Advanced Technologies
22
發行號12
DOIs
出版狀態已發佈 - 2011 十二月 1

ASJC Scopus subject areas

  • Polymers and Plastics

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