The Distribution of Autoantibodies by Age Group in Children with Type 1 Diabetes versus Type 2 Diabetes in Southern Vietnam

Quynh Thi Vu Huynh, Minh Thi Tuyet Trinh, Khang Kim Doan, Ban Tran Ho, Szu Chuan Shen, Tung Huu Trinh, Thanh Hoa Vo, Nguyen Quoc Khanh Le*, Ngan Thi Kim Nguyen*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

Asian children are increasingly being diagnosed with type 1 diabetes (T1D) or type 2 diabetes (T2D), and the presence of coexisting islet autoimmune antibodies complicate diagnosis. Here, we aimed to determine the prevalence of islet cell autoantibodies (ICAs) and glutamic acid decarboxylase 65 autoantibodies (GADAs) in children with T1D versus T2D living in Vietnam. This cross-sectional study included 145 pediatric patients aged 10.3 ± 3.6 years, with 53.1% and 46.9% having T1D and T2D, respectively. ICAs were reported in only 3.9% of pediatric T1Ds, which was not significantly different from the 1.5% of those with T2D. Older children with T1D were positive for either ICAs, or ICAs and GADAs (5–9 and 10–15 years), whereas only a small proportion of children aged 0–4 years were positive for GADAs (18%). Notably, 27.9% of children with T2D aged 10–15 were positive for GADAs, and all were classified as overweight (n = 9) or obese (n = 10). GADAs were more commonly observed in T1D patients younger than four years than ICAs, which were more prevalent in older children (5–15 years). Even though few children with T2D carried ICAs and GADAs, finding a better biomarker or an appropriate time to confirm diabetes type may require further investigation.

原文英語
文章編號1420
期刊Journal of Clinical Medicine
12
發行號4
DOIs
出版狀態已發佈 - 2023 2月

ASJC Scopus subject areas

  • 一般醫學

指紋

深入研究「The Distribution of Autoantibodies by Age Group in Children with Type 1 Diabetes versus Type 2 Diabetes in Southern Vietnam」主題。共同形成了獨特的指紋。

引用此