Tandem three-component reaction of aldehyde, alkyl acrylate, and amide using ethyl diphenylphosphine as organocatalyst

Siang En Syu, De Wei Wang, Pei Yi Chen, Yi Ting Hung, Yi Wun Jhang, Tzu Ting Kao, Yu Ting Lee, Wenwei Lin

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

It is the first time that a chemoselective EtPPh2-catalyzed three-component reaction of aromatic aldehyde, alkyl acrylate, and phthalimide or methyl toluenesulfonamide has been achieved. A variety of highly functional adducts can be generated efficiently in one step within 1-72 h in 38-93% yields. The reaction mechanism is proposed to undergo Morita-Baylis-Hillman reactions of aryl-substituted aldehydes and alkyl acrylates followed by Michael additions of amides. Our studies indicated that, in combination of EtPPh2, alkyl acrylate also catalyzed this process.

原文英語
頁(從 - 到)5943-5946
頁數4
期刊Tetrahedron Letters
51
發行號45
DOIs
出版狀態已發佈 - 2010 十一月 10

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

指紋 深入研究「Tandem three-component reaction of aldehyde, alkyl acrylate, and amide using ethyl diphenylphosphine as organocatalyst」主題。共同形成了獨特的指紋。

引用此