Synthesis of Unsymmetrical Urea Derivatives via Cu-Catalyzed Reaction of Acylazide and Secondary Amine

Jivan Shinde; Prakash Bhimrao Patil; Veerababurao Kavala; Ching Fa Yao

doi:10.1002/cbdv.202200346

Synthesis of Unsymmetrical Urea Derivatives via Cu-Catalyzed Reaction of Acylazide and Secondary Amine

Jivan Shinde
, Prakash Bhimrao Patil
, Veerababurao Kavala
, Ching Fa Yao^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

4 引文斯高帕斯（Scopus）

摘要

The synthesis of unsymmetrical urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu-catalyzed greener and safer unsymmetrical urea derivatives synthesis in ethyl acetate. This method minimized utilization of toxic reagent. A variety of indole, amines, and azides with bis-indole successfully employed leading to high yields and gram scale synthesis of isolated urea.

原文	英語
文章編號	e202200346
期刊	Chemistry and Biodiversity
卷	19
發行號	8
DOIs	https://doi.org/10.1002/cbdv.202200346
出版狀態	已發佈 - 2022 8月

ASJC Scopus subject areas

生物工程
生物化學
一般化學
分子醫學
分子生物學

存取文件

10.1002/cbdv.202200346

其它文件與鏈接

CCDC 2151491: Experimental Crystal Structure Determination
Shinde, J. (Contributor), Bhimrao Patil, P. (Contributor), Kavala, V. (Contributor) & Yao, C.-F. (Contributor), Cambridge Crystallographic Data Centre, 2023
DOI: 10.5517/ccdc.csd.cc2b6sy9, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2b6sy9&sid=DataCite
資料集: Dataset
CCDC 2151828: Experimental Crystal Structure Determination
Shinde, J. (Contributor), Bhimrao Patil, P. (Contributor), Kavala, V. (Contributor) & Yao, C.-F. (Contributor), Cambridge Crystallographic Data Centre, 2023
DOI: 10.5517/ccdc.csd.cc2b74tk, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2b74tk&sid=DataCite
資料集: Dataset
CCDC 2152492: Experimental Crystal Structure Determination
Shinde, J. (Contributor), Bhimrao Patil, P. (Contributor), Kavala, V. (Contributor) & Yao, C.-F. (Contributor), Cambridge Crystallographic Data Centre, 2023
DOI: 10.5517/ccdc.csd.cc2b7v7p, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2b7v7p&sid=DataCite
資料集: Dataset

引用此

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title = "Synthesis of Unsymmetrical Urea Derivatives via Cu-Catalyzed Reaction of Acylazide and Secondary Amine",

abstract = "The synthesis of unsymmetrical urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu-catalyzed greener and safer unsymmetrical urea derivatives synthesis in ethyl acetate. This method minimized utilization of toxic reagent. A variety of indole, amines, and azides with bis-indole successfully employed leading to high yields and gram scale synthesis of isolated urea.",

keywords = "Curtius rearrangement, copper catalyst, green solvent, unsymmetrical urea",

author = "Jivan Shinde and \{Bhimrao Patil\}, Prakash and Veerababurao Kavala and Yao, \{Ching Fa\}",

note = "Publisher Copyright: {\textcopyright} 2022 Wiley-VHCA AG, Zurich, Switzerland.",

year = "2022",

month = aug,

doi = "10.1002/cbdv.202200346",

language = "English",

volume = "19",

journal = "Chemistry and Biodiversity",

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AU - Shinde, Jivan

AU - Bhimrao Patil, Prakash

AU - Kavala, Veerababurao

AU - Yao, Ching Fa

PY - 2022/8

Y1 - 2022/8

N2 - The synthesis of unsymmetrical urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu-catalyzed greener and safer unsymmetrical urea derivatives synthesis in ethyl acetate. This method minimized utilization of toxic reagent. A variety of indole, amines, and azides with bis-indole successfully employed leading to high yields and gram scale synthesis of isolated urea.

AB - The synthesis of unsymmetrical urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu-catalyzed greener and safer unsymmetrical urea derivatives synthesis in ethyl acetate. This method minimized utilization of toxic reagent. A variety of indole, amines, and azides with bis-indole successfully employed leading to high yields and gram scale synthesis of isolated urea.

KW - Curtius rearrangement

KW - copper catalyst

KW - green solvent

KW - unsymmetrical urea

UR - https://www.scopus.com/pages/publications/85134023821

UR - https://www.scopus.com/pages/publications/85134023821#tab=citedBy

U2 - 10.1002/cbdv.202200346

DO - 10.1002/cbdv.202200346

M3 - Article

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AN - SCOPUS:85134023821

SN - 1612-1872

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JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 8

M1 - e202200346

ER -

Synthesis of Unsymmetrical Urea Derivatives via Cu-Catalyzed Reaction of Acylazide and Secondary Amine

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

資料集

CCDC 2151491: Experimental Crystal Structure Determination

CCDC 2151828: Experimental Crystal Structure Determination

CCDC 2152492: Experimental Crystal Structure Determination

引用此