Synthesis of Unsymmetrical Urea Derivatives via Cu-Catalyzed Reaction of Acylazide and Secondary Amine

Jivan Shinde; Prakash Bhimrao Patil; Veerababurao Kavala; Ching Fa Yao

doi:10.1002/cbdv.202200346

Synthesis of Unsymmetrical Urea Derivatives via Cu-Catalyzed Reaction of Acylazide and Secondary Amine

Jivan Shinde, Prakash Bhimrao Patil, Veerababurao Kavala, Ching Fa Yao^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

1 引文斯高帕斯（Scopus）

摘要

The synthesis of unsymmetrical urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu-catalyzed greener and safer unsymmetrical urea derivatives synthesis in ethyl acetate. This method minimized utilization of toxic reagent. A variety of indole, amines, and azides with bis-indole successfully employed leading to high yields and gram scale synthesis of isolated urea.

原文	英語
文章編號	e202200346
期刊	Chemistry and Biodiversity
卷	19
發行號	8
DOIs	https://doi.org/10.1002/cbdv.202200346
出版狀態	已發佈 - 2022 8月

ASJC Scopus subject areas

生物工程
生物化學
一般化學
分子醫學
分子生物學

存取文件

10.1002/cbdv.202200346

其它文件與鏈接

CCDC 2152492: Experimental Crystal Structure Determination
Shinde, J. (Contributor), Bhimrao Patil, P. (Contributor), Kavala, V. (Contributor) & Yao, C.-F. (Contributor), Cambridge Crystallographic Data Centre, 2023
DOI: 10.5517/ccdc.csd.cc2b7v7p, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2b7v7p&sid=DataCite
資料集: Dataset
CCDC 2151819: Experimental Crystal Structure Determination
Shinde, J. (Contributor), Bhimrao Patil, P. (Contributor), Kavala, V. (Contributor) & Yao, C.-F. (Contributor), Cambridge Crystallographic Data Centre, 2023
DOI: 10.5517/ccdc.csd.cc2b74j8, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2b74j8&sid=DataCite
資料集: Dataset
CCDC 2151821: Experimental Crystal Structure Determination
Shinde, J. (Contributor), Bhimrao Patil, P. (Contributor), Kavala, V. (Contributor) & Yao, C.-F. (Contributor), Cambridge Crystallographic Data Centre, 2023
DOI: 10.5517/ccdc.csd.cc2b74lb, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2b74lb&sid=DataCite
資料集: Dataset

引用此

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abstract = "The synthesis of unsymmetrical urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu-catalyzed greener and safer unsymmetrical urea derivatives synthesis in ethyl acetate. This method minimized utilization of toxic reagent. A variety of indole, amines, and azides with bis-indole successfully employed leading to high yields and gram scale synthesis of isolated urea.",

keywords = "Curtius rearrangement, copper catalyst, green solvent, unsymmetrical urea",

author = "Jivan Shinde and {Bhimrao Patil}, Prakash and Veerababurao Kavala and Yao, {Ching Fa}",

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year = "2022",

month = aug,

doi = "10.1002/cbdv.202200346",

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AU - Yao, Ching Fa

PY - 2022/8

Y1 - 2022/8

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AB - The synthesis of unsymmetrical urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu-catalyzed greener and safer unsymmetrical urea derivatives synthesis in ethyl acetate. This method minimized utilization of toxic reagent. A variety of indole, amines, and azides with bis-indole successfully employed leading to high yields and gram scale synthesis of isolated urea.

KW - Curtius rearrangement

KW - copper catalyst

KW - green solvent

KW - unsymmetrical urea

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ER -

Synthesis of Unsymmetrical Urea Derivatives via Cu-Catalyzed Reaction of Acylazide and Secondary Amine

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

資料集

CCDC 2152492: Experimental Crystal Structure Determination

CCDC 2151819: Experimental Crystal Structure Determination

CCDC 2151821: Experimental Crystal Structure Determination

引用此