摘要
A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities.
原文 | 英語 |
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文章編號 | 6251 |
期刊 | International journal of molecular sciences |
卷 | 22 |
發行號 | 12 |
DOIs | |
出版狀態 | 已發佈 - 2021 6月 2 |
ASJC Scopus subject areas
- 催化
- 分子生物學
- 光譜
- 電腦科學應用
- 物理與理論化學
- 有機化學
- 無機化學
指紋
深入研究「Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing」主題。共同形成了獨特的指紋。資料集
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CCDC 1863526: Experimental Crystal Structure Determination
Liou, Y. (Contributor), Lin, Y. (Contributor), Wang, K. (Contributor), Yang, J. (Contributor), Jang, Y. (Contributor), Lin, W. (Contributor) & Wu, Y. (Contributor), Cambridge Crystallographic Data Centre, 2021
DOI: 10.5517/ccdc.csd.cc20k4rh, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc20k4rh&sid=DataCite
資料集: Dataset