@article{d59a5d6485b94ba5999dfc975a7d0ebe,
title = "Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing",
abstract = "A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities.",
keywords = "1,3-indandione, One-pot reaction, Spiro-tetrahydroquinoline, Tetrahydroquinoline, Wound healing",
author = "Liou, {Yan Cheng} and Lin, {Yan An} and Ke Wang and Yang, {Juan Cheng} and Jang, {Yeong Jiunn} and Wenwei Lin and Wu, {Yang Chang}",
note = "Funding Information: Funding: This work is supported by the Ministry of Science and Technology, Taiwan (MOST 107-2628-M-003-001-MY3, MOST 109-2320-B-039-063-, MOST 107-2320-B-039-017-MY3, and MOST 108-2113-M-039-005-) and China Medical University, Taiwan (CMU108-MF-96) for financial support. Publisher Copyright: {\textcopyright} 2021 by the authorsLicensee MDPI, Basel, Switzerland.",
year = "2021",
month = jun,
day = "2",
doi = "10.3390/ijms22126251",
language = "English",
volume = "22",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",
}