Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing

Yan Cheng Liou; Yan An Lin; Ke Wang; Juan Cheng Yang; Yeong Jiunn Jang; Wenwei Lin; Yang Chang Wu

doi:10.3390/ijms22126251

Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing

Yan Cheng Liou, Yan An Lin, Ke Wang, Juan Cheng Yang, Yeong Jiunn Jang^*, Wenwei Lin, Yang Chang Wu

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

3 引文斯高帕斯（Scopus）

摘要

A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by¹ H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities.

原文	英語
文章編號	6251
期刊	International journal of molecular sciences
卷	22
發行號	12
DOIs	https://doi.org/10.3390/ijms22126251
出版狀態	已發佈 - 2021 6月 2

ASJC Scopus subject areas

催化
分子生物學
光譜
電腦科學應用
物理與理論化學
有機化學
無機化學

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10.3390/ijms22126251

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Link to publication in Scopus

CCDC 1863526: Experimental Crystal Structure Determination
Liou, Y. (Contributor), Lin, Y. (Contributor), Wang, K. (Contributor), Yang, J. (Contributor), Jang, Y. (Contributor), Lin, W. (Contributor) & Wu, Y. (Contributor), Cambridge Crystallographic Data Centre, 2021
DOI: 10.5517/ccdc.csd.cc20k4rh, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc20k4rh&sid=DataCite
資料集: Dataset

引用此

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title = "Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing",

abstract = "A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities.",

keywords = "1,3-indandione, One-pot reaction, Spiro-tetrahydroquinoline, Tetrahydroquinoline, Wound healing",

author = "Liou, {Yan Cheng} and Lin, {Yan An} and Ke Wang and Yang, {Juan Cheng} and Jang, {Yeong Jiunn} and Wenwei Lin and Wu, {Yang Chang}",

note = "Funding Information: Funding: This work is supported by the Ministry of Science and Technology, Taiwan (MOST 107-2628-M-003-001-MY3, MOST 109-2320-B-039-063-, MOST 107-2320-B-039-017-MY3, and MOST 108-2113-M-039-005-) and China Medical University, Taiwan (CMU108-MF-96) for financial support. Publisher Copyright: {\textcopyright} 2021 by the authorsLicensee MDPI, Basel, Switzerland.",

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doi = "10.3390/ijms22126251",

language = "English",

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AU - Liou, Yan Cheng

AU - Lin, Yan An

AU - Wang, Ke

AU - Yang, Juan Cheng

AU - Jang, Yeong Jiunn

AU - Lin, Wenwei

AU - Wu, Yang Chang

N1 - Funding Information: Funding: This work is supported by the Ministry of Science and Technology, Taiwan (MOST 107-2628-M-003-001-MY3, MOST 109-2320-B-039-063-, MOST 107-2320-B-039-017-MY3, and MOST 108-2113-M-039-005-) and China Medical University, Taiwan (CMU108-MF-96) for financial support. Publisher Copyright: © 2021 by the authorsLicensee MDPI, Basel, Switzerland.

PY - 2021/6/2

Y1 - 2021/6/2

N2 - A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities.

AB - A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities.

KW - 1,3-indandione

KW - One-pot reaction

KW - Spiro-tetrahydroquinoline

KW - Tetrahydroquinoline

KW - Wound healing

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JF - International Journal of Molecular Sciences

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Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

資料集

CCDC 1863526: Experimental Crystal Structure Determination

引用此