Synthesis of novel spiro-tetrahydroquinoline derivatives and evaluation of their pharmacological effects on wound healing

Yan Cheng Liou, Yan An Lin, Ke Wang, Juan Cheng Yang, Yeong Jiunn Jang*, Wenwei Lin, Yang Chang Wu

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by1 H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities.

原文英語
文章編號6251
期刊International journal of molecular sciences
22
發行號12
DOIs
出版狀態已發佈 - 2021 六月 2

ASJC Scopus subject areas

  • 催化
  • 分子生物學
  • 光譜
  • 電腦科學應用
  • 物理與理論化學
  • 有機化學
  • 無機化學

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