Synthesis of Multifunctional Alkenes from Substituted Acrylates and Aldehydes via Phosphine-Catalyzed Wittig Reaction

Yi Ling Tsai; Wenwei Lin

doi:10.1002/ajoc.201500251

Synthesis of Multifunctional Alkenes from Substituted Acrylates and Aldehydes via Phosphine-Catalyzed Wittig Reaction

Yi Ling Tsai, Wenwei Lin^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

23 引文斯高帕斯（Scopus）

摘要

An efficient synthesis of multifunctional alkenes starting from substituted acrylates and aldehydes has been developed via phosphine-catalyzed Wittig reactions. The reactions proceed smoothly even under mild conditions (30-60°C) via a phosphine/phosphine oxide catalytic cycle using phenyl silane as the reducing agent. According to this simple protocol, the desired products are obtained in moderate to excellent yields as single stereoisomers.

原文	英語
頁（從 - 到）	1040-1043
頁數	4
期刊	Asian Journal of Organic Chemistry
卷	4
發行號	10
DOIs	https://doi.org/10.1002/ajoc.201500251
出版狀態	已發佈 - 2015 10月 1

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abstract = "An efficient synthesis of multifunctional alkenes starting from substituted acrylates and aldehydes has been developed via phosphine-catalyzed Wittig reactions. The reactions proceed smoothly even under mild conditions (30-60°C) via a phosphine/phosphine oxide catalytic cycle using phenyl silane as the reducing agent. According to this simple protocol, the desired products are obtained in moderate to excellent yields as single stereoisomers.",

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author = "Tsai, {Yi Ling} and Wenwei Lin",

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N2 - An efficient synthesis of multifunctional alkenes starting from substituted acrylates and aldehydes has been developed via phosphine-catalyzed Wittig reactions. The reactions proceed smoothly even under mild conditions (30-60°C) via a phosphine/phosphine oxide catalytic cycle using phenyl silane as the reducing agent. According to this simple protocol, the desired products are obtained in moderate to excellent yields as single stereoisomers.

AB - An efficient synthesis of multifunctional alkenes starting from substituted acrylates and aldehydes has been developed via phosphine-catalyzed Wittig reactions. The reactions proceed smoothly even under mild conditions (30-60°C) via a phosphine/phosphine oxide catalytic cycle using phenyl silane as the reducing agent. According to this simple protocol, the desired products are obtained in moderate to excellent yields as single stereoisomers.

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KW - Alkenes

KW - Wittig reaction

KW - Ylides

KW - Zwitterions

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Synthesis of Multifunctional Alkenes from Substituted Acrylates and Aldehydes via Phosphine-Catalyzed Wittig Reaction

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