An efficient synthesis of multifunctional alkenes starting from substituted acrylates and aldehydes has been developed via phosphine-catalyzed Wittig reactions. The reactions proceed smoothly even under mild conditions (30-60°C) via a phosphine/phosphine oxide catalytic cycle using phenyl silane as the reducing agent. According to this simple protocol, the desired products are obtained in moderate to excellent yields as single stereoisomers.
ASJC Scopus subject areas
- Organic Chemistry