摘要
A Bu3P-mediated mild and efficient synthesis of multi-functional alkenes has been described starting from substituted acrylate with aldehydes. In situ generated zwitterionic intermediates underwent proton-exchange to afford ylide intermediates, which were trapped by corresponding aldehydes providing the products in up to 92% yield with complete E-stereoselectivity. Further derivatization of the products was performed to furnish functional pyridazinones.
原文 | 英語 |
---|---|
頁(從 - 到) | 5038-5045 |
頁數 | 8 |
期刊 | Tetrahedron |
卷 | 70 |
發行號 | 34 |
DOIs | |
出版狀態 | 已發佈 - 2014 8月 26 |
ASJC Scopus subject areas
- 生物化學
- 藥物發現
- 有機化學
指紋
深入研究「Synthesis of multi-functional alkenes via Wittig reaction with a new-type of phosphorus ylides」主題。共同形成了獨特的指紋。資料集
-
CCDC 986508: Experimental Crystal Structure Determination
Tsai, Y. (Creator), Syu, S. (Creator), Yang, S. (Creator), Das, U. (Creator), Fan, Y. (Creator), Lee, C. (Creator) & Lin, W. (Creator), Unknown Publisher, 2014
DOI: 10.5517/cc123jvk, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc123jvk&sid=DataCite
資料集: Dataset
-
CCDC 986509: Experimental Crystal Structure Determination
Tsai, Y. (Creator), Syu, S. (Creator), Yang, S. (Creator), Das, U. (Creator), Fan, Y. (Creator), Lee, C. (Creator) & Lin, W. (Creator), Unknown Publisher, 2014
DOI: 10.5517/cc123jwl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc123jwl&sid=DataCite
資料集: Dataset
-
CCDC 986510: Experimental Crystal Structure Determination
Tsai, Y. (Creator), Syu, S. (Creator), Yang, S. (Creator), Das, U. (Creator), Fan, Y. (Creator), Lee, C. (Creator) & Lin, W. (Creator), Unknown Publisher, 2014
DOI: 10.5517/cc123jxm, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc123jxm&sid=DataCite
資料集: Dataset