Synthesis of fused isoquinolinone and iminoisoindolinone derivatives via a copper-catalyzed regioselective switching process

Veerababurao Kavala, Cheng Chuan Wang, Yu Hsuan Wang, Chun Wei Kuo, Donala Janreddy, Wen Chang Huang, Ting Shen Kuo, Chiu Hui He, Mei Ling Chen, Ching-Fa Yao

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

摘要

Copper-catalyzed base switching procedures for the synthesis of various fused isoquinolinone derivatives and iminoisoindolinone derivatives from the same starting materials have been developed. In these reaction sequences it is found that benzyl cyanide acts as a nucleophile in the presence of strong bases while it acts as a cyanide donor in the presence of weak bases. A wide substrate scope, good functional group tolerance, and handy reaction conditions are the important features of these protocols. Futhermore, using these protocols a wide variety of imidazolone-fused isoquinolinone derivatives, pyrimidinone-fused isoquinolinone derivatives, a diazapinone-fused isoquinolinone derivative and iminoisoindolinone derivatives were accessed in excellent to moderate yields.

原文英語
頁(從 - 到)2609-2626
頁數18
期刊Advanced Synthesis and Catalysis
356
發行號11-12
DOIs
出版狀態已發佈 - 2014 八月 11

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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    Kavala, V., Wang, C. C., Wang, Y. H., Kuo, C. W., Janreddy, D., Huang, W. C., Kuo, T. S., He, C. H., Chen, M. L., & Yao, C-F. (2014). Synthesis of fused isoquinolinone and iminoisoindolinone derivatives via a copper-catalyzed regioselective switching process. Advanced Synthesis and Catalysis, 356(11-12), 2609-2626. https://doi.org/10.1002/adsc.201301105