Synthesis of Functionalized Furans via Chemoselective Reduction/Wittig Reaction Using Catalytic Triethylamine and Phosphine

Chia Jui Lee, Tzu Hsiu Chang, Jhen Kuei Yu, Ganapuram Madhusudhan Reddy, Ming Yu Hsiao, Wenwei Lin*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

52 引文 斯高帕斯(Scopus)

摘要

An efficient protocol for the synthesis of highly functionalized furans via intramolecular Wittig reaction has been developed using catalytic amounts of phosphine and triethylamine. Silyl chloride served as the initial promoter to activate the phosphine oxide. Reduction of the activated phosphine oxide by hydrosilane resulted in generation of phosphine, while decomposition of Et3N·HCl resulted in regeneration of base, which mediated formation of phosphorus ylide. Remarkably, the in situ generated byproduct, Et3N·HCl, also catalyzes reduction of phosphine oxide.

原文英語
頁(從 - 到)3758-3761
頁數4
期刊Organic Letters
18
發行號15
DOIs
出版狀態已發佈 - 2016 八月 5

ASJC Scopus subject areas

  • 生物化學
  • 物理與理論化學
  • 有機化學

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