Synthesis of chromeno[4,3-b]pyrrolidines from azomethine ylides and vinyl para-quinone methides via (3 + 2) cycloaddition/oxa-1,6-addition

Pei Shan Wu, Yan Cheng Liou, Gangababu Marri, Yi Ru Chen, Jia Rong Wu, Wenwei Lin*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

摘要

An efficient synthesis of chromeno[4,3-b]pyrrolidines has been successfully developed. This strategy involves a base-catalyzed reaction of p-VQMs and o-hydroxy azomethine ylides via (3 + 2) cycloaddition/oxa-1,6-addition reaction sequence. The reaction condition is mild, and a series of chromeno[4,3-b]pyrrolidines were obtained in 49-95% yields with excellent diastereoselectivity (dr > 20:1).

原文英語
頁(從 - 到)2136-2146
頁數11
期刊Journal of the Chinese Chemical Society
70
發行號12
DOIs
出版狀態已發佈 - 2023 12月

ASJC Scopus subject areas

  • 一般化學

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