Synthesis of bicyclic isoxazoles and isoxazolines via intramolecular nitrile oxide cycloaddition

Wen Chang Chen; Veerababurao Kavala; Yu Hsuan Shih; Yu Hsuan Wang; Chun Wei Kuo; Tang Hao Yang; Chia Yu Huang; Hao Hsiang Chiu; Ching Fa Yao

doi:10.3390/molecules200610910

Synthesis of bicyclic isoxazoles and isoxazolines via intramolecular nitrile oxide cycloaddition

Wen Chang Chen, Veerababurao Kavala, Yu Hsuan Shih, Yu Hsuan Wang, Chun Wei Kuo, Tang Hao Yang, Chia Yu Huang, Hao Hsiang Chiu, Ching Fa Yao^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

6 引文斯高帕斯（Scopus）

摘要

An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology. bicyclic isoxazole/isoxazolines; cycloaddition; nitrile oxide; nitroalkane; Yamaguchi reagent.

原文	英語
頁（從 - 到）	10910-10927
頁數	18
期刊	Molecules
卷	20
發行號	6
DOIs	https://doi.org/10.3390/molecules200610910
出版狀態	已發佈 - 2015 6月 1

ASJC Scopus subject areas

分析化學
化學（雜項）
分子醫學
藥學科學
藥物發現
物理與理論化學
有機化學

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10.3390/molecules200610910

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title = "Synthesis of bicyclic isoxazoles and isoxazolines via intramolecular nitrile oxide cycloaddition",

abstract = "An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology. bicyclic isoxazole/isoxazolines; cycloaddition; nitrile oxide; nitroalkane; Yamaguchi reagent.",

author = "Chen, {Wen Chang} and Veerababurao Kavala and Shih, {Yu Hsuan} and Wang, {Yu Hsuan} and Kuo, {Chun Wei} and Yang, {Tang Hao} and Huang, {Chia Yu} and Chiu, {Hao Hsiang} and Yao, {Ching Fa}",

year = "2015",

month = jun,

day = "1",

doi = "10.3390/molecules200610910",

language = "English",

volume = "20",

pages = "10910--10927",

journal = "Molecules",

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TY - JOUR

T1 - Synthesis of bicyclic isoxazoles and isoxazolines via intramolecular nitrile oxide cycloaddition

AU - Chen, Wen Chang

AU - Kavala, Veerababurao

AU - Shih, Yu Hsuan

AU - Wang, Yu Hsuan

AU - Kuo, Chun Wei

AU - Yang, Tang Hao

AU - Huang, Chia Yu

AU - Chiu, Hao Hsiang

AU - Yao, Ching Fa

PY - 2015/6/1

Y1 - 2015/6/1

N2 - An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology. bicyclic isoxazole/isoxazolines; cycloaddition; nitrile oxide; nitroalkane; Yamaguchi reagent.

AB - An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology. bicyclic isoxazole/isoxazolines; cycloaddition; nitrile oxide; nitroalkane; Yamaguchi reagent.

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DO - 10.3390/molecules200610910

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C2 - 26076111

AN - SCOPUS:84938227488

SN - 1420-3049

VL - 20

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JO - Molecules

JF - Molecules

IS - 6

ER -

Synthesis of bicyclic isoxazoles and isoxazolines via intramolecular nitrile oxide cycloaddition

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