摘要
6-Cyanouracil derivatives underwent a direct nucleophilic substitution reaction with alkyl Grignard reagents in the presence of zinc(II) chloride as a catalyst to form the corresponding 6-alkyluracils. This methodology is applicable to sugar-protected 6-cyanouridine and 6-cyano-2′-deoxyuridine without the protection at the N3-imide and provides a facile and general access to versatile 6-alkyluracil and 6-alkyluridine derivatives.
原文 | 英語 |
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頁(從 - 到) | 4027-4036 |
頁數 | 10 |
期刊 | Journal of Organic Chemistry |
卷 | 78 |
發行號 | 8 |
DOIs | |
出版狀態 | 已發佈 - 2013 4月 19 |
ASJC Scopus subject areas
- 有機化學
指紋
深入研究「Synthesis of 6-alkyluridines from 6-cyanouridine via zinc(II) chloride-catalyzed nucleophilic substitution with alkyl grignard reagents」主題。共同形成了獨特的指紋。資料集
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CCDC 948779: Experimental Crystal Structure Determination
Shih, Y. (Creator), Yang, Y. (Creator), Lin, C. (Creator) & Chien, T. (Creator), Unknown Publisher, 2013
DOI: 10.5517/cc10v8sx, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc10v8sx&sid=DataCite
資料集: Dataset
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CCDC 948780: Experimental Crystal Structure Determination
Shih, Y. (Creator), Yang, Y. (Creator), Lin, C. (Creator) & Chien, T. (Creator), Unknown Publisher, 2013
DOI: 10.5517/cc10v8ty, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc10v8ty&sid=DataCite
資料集: Dataset