Synthesis of 6-alkyluridines from 6-cyanouridine via zinc(II) chloride-catalyzed nucleophilic substitution with alkyl grignard reagents

Yu Chiao Shih, Ya Ying Yang, Chun Chi Lin, Tun-Cheng Chien

研究成果: 雜誌貢獻期刊論文同行評審

7 引文 斯高帕斯(Scopus)

摘要

6-Cyanouracil derivatives underwent a direct nucleophilic substitution reaction with alkyl Grignard reagents in the presence of zinc(II) chloride as a catalyst to form the corresponding 6-alkyluracils. This methodology is applicable to sugar-protected 6-cyanouridine and 6-cyano-2′-deoxyuridine without the protection at the N3-imide and provides a facile and general access to versatile 6-alkyluracil and 6-alkyluridine derivatives.

原文英語
頁(從 - 到)4027-4036
頁數10
期刊Journal of Organic Chemistry
78
發行號8
DOIs
出版狀態已發佈 - 2013 四月 19

ASJC Scopus subject areas

  • Organic Chemistry

指紋 深入研究「Synthesis of 6-alkyluridines from 6-cyanouridine via zinc(II) chloride-catalyzed nucleophilic substitution with alkyl grignard reagents」主題。共同形成了獨特的指紋。

引用此