Synthesis of 2-azaspiro[4.6]undec-7-enes from N -tosyl- N -(3-arylpropargyl)-tethered 3-methylcyclohex-2-en-1-ols

Ming-Chang P. Yeh, Chia Jung Liang, Chern Wei Fan, Wei Hang Chiu, Jun Yuan Lo

研究成果: 雜誌貢獻文章同行評審

15 引文 斯高帕斯(Scopus)

摘要

The FeCl3-promoted synthesis of 2-azaspiro[4.6]undec-7-ene rings proceeds via ring expansion/cyclization/chlorination of N-tosyl-N-(3- arylpropargyl)-tethered 6-methylbicyclo[4.1.0]heptan-2-ols. This azaspirocyclic ring skeleton can also be obtained in one pot from the tert-butyldimethylsilyl- protected N-tosyl-N-(3-arylpropargyl)-tethered 3-methylcyclohex-2-en-1-ols and diethylzinc/diiodomethane.

原文英語
頁(從 - 到)9707-9717
頁數11
期刊Journal of Organic Chemistry
77
發行號21
DOIs
出版狀態已發佈 - 2012 十一月 2

ASJC Scopus subject areas

  • Organic Chemistry

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