摘要
The FeCl3-promoted synthesis of 2-azaspiro[4.6]undec-7-ene rings proceeds via ring expansion/cyclization/chlorination of N-tosyl-N-(3- arylpropargyl)-tethered 6-methylbicyclo[4.1.0]heptan-2-ols. This azaspirocyclic ring skeleton can also be obtained in one pot from the tert-butyldimethylsilyl- protected N-tosyl-N-(3-arylpropargyl)-tethered 3-methylcyclohex-2-en-1-ols and diethylzinc/diiodomethane.
原文 | 英語 |
---|---|
頁(從 - 到) | 9707-9717 |
頁數 | 11 |
期刊 | Journal of Organic Chemistry |
卷 | 77 |
發行號 | 21 |
DOIs | |
出版狀態 | 已發佈 - 2012 十一月 2 |
ASJC Scopus subject areas
- Organic Chemistry