Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction

Veerababurao Kavala; Zonghan Yang; Ashok Konala; Tang Hao Yang; Chun Wei Kuo; Jian Yao Ruan; Ching Fa Yao

doi:10.1002/ejoc.201701618

Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction

Veerababurao Kavala
, Zonghan Yang
, Ashok Konala
, Tang Hao Yang
, Chun Wei Kuo
, Jian Yao Ruan
, Ching Fa Yao^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

17 引文斯高帕斯（Scopus）

摘要

A one-pot reaction has been devloped for the preparation of 1,2,3-fused indole polyheterocycles by starting from 2-iodobenzamide and 2-iodobenzyl cyanide in the presence of a copper catalyst. The cascade process involves the efficient formation of one C–C and three C–N bonds. A broad substrate scope, good yields, and short reactions times are key features of this strategy.

原文	英語
頁（從 - 到）	1241-1247
頁數	7
期刊	European Journal of Organic Chemistry
卷	2018
發行號	10
DOIs	https://doi.org/10.1002/ejoc.201701618
出版狀態	已發佈 - 2018 3月 14

ASJC Scopus subject areas

物理與理論化學
有機化學

存取文件

10.1002/ejoc.201701618

其它文件與鏈接

CCDC 1812835: Experimental Crystal Structure Determination
Kavala, V. (Contributor), Yang, Z. (Contributor), Konala, A. (Contributor), Yang, T.-H. (Contributor), Kuo, C.-W. (Contributor), Ruan, J.-Y. (Contributor) & Yao, C.-F. (Contributor), Unknown Publisher, 2018
DOI: 10.5517/ccdc.csd.cc1yvdkr, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1yvdkr&sid=DataCite
資料集: Dataset
CCDC 1812834: Experimental Crystal Structure Determination
Kavala, V. (Contributor), Yang, Z. (Contributor), Konala, A. (Contributor), Yang, T.-H. (Contributor), Kuo, C.-W. (Contributor), Ruan, J.-Y. (Contributor) & Yao, C.-F. (Contributor), Unknown Publisher, 2018
DOI: 10.5517/ccdc.csd.cc1yvdjq, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1yvdjq&sid=DataCite
資料集: Dataset

引用此

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title = "Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction",

abstract = "A one-pot reaction has been devloped for the preparation of 1,2,3-fused indole polyheterocycles by starting from 2-iodobenzamide and 2-iodobenzyl cyanide in the presence of a copper catalyst. The cascade process involves the efficient formation of one C–C and three C–N bonds. A broad substrate scope, good yields, and short reactions times are key features of this strategy.",

keywords = "Copper, Domino reactions, Nitrogen heterocycles, Polycycles, Synthetic methods",

author = "Veerababurao Kavala and Zonghan Yang and Ashok Konala and Yang, \{Tang Hao\} and Kuo, \{Chun Wei\} and Ruan, \{Jian Yao\} and Yao, \{Ching Fa\}",

note = "Publisher Copyright: {\textcopyright} 2018 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2018",

month = mar,

day = "14",

doi = "10.1002/ejoc.201701618",

language = "English",

volume = "2018",

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journal = "European Journal of Organic Chemistry",

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TY - JOUR

T1 - Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction

AU - Kavala, Veerababurao

AU - Yang, Zonghan

AU - Konala, Ashok

AU - Yang, Tang Hao

AU - Kuo, Chun Wei

AU - Ruan, Jian Yao

AU - Yao, Ching Fa

PY - 2018/3/14

Y1 - 2018/3/14

N2 - A one-pot reaction has been devloped for the preparation of 1,2,3-fused indole polyheterocycles by starting from 2-iodobenzamide and 2-iodobenzyl cyanide in the presence of a copper catalyst. The cascade process involves the efficient formation of one C–C and three C–N bonds. A broad substrate scope, good yields, and short reactions times are key features of this strategy.

AB - A one-pot reaction has been devloped for the preparation of 1,2,3-fused indole polyheterocycles by starting from 2-iodobenzamide and 2-iodobenzyl cyanide in the presence of a copper catalyst. The cascade process involves the efficient formation of one C–C and three C–N bonds. A broad substrate scope, good yields, and short reactions times are key features of this strategy.

KW - Copper

KW - Domino reactions

KW - Nitrogen heterocycles

KW - Polycycles

KW - Synthetic methods

UR - https://www.scopus.com/pages/publications/85043706273

UR - https://www.scopus.com/pages/publications/85043706273#tab=citedBy

U2 - 10.1002/ejoc.201701618

DO - 10.1002/ejoc.201701618

M3 - Article

AN - SCOPUS:85043706273

SN - 1434-193X

VL - 2018

SP - 1241

EP - 1247

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 10

ER -

Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

資料集

CCDC 1812835: Experimental Crystal Structure Determination

CCDC 1812834: Experimental Crystal Structure Determination

引用此