Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen Shan Li*, Shivaji V. More, Chie Hong Wang, Ya Ching Jen, Ching Fa Yao, Tein Fu Wang, Chin Chun Hung, Shu Chuan Jao

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

13 引文 斯高帕斯(Scopus)

摘要

This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

原文英語
頁(從 - 到)1148-1152
頁數5
期刊Bioorganic and Medicinal Chemistry Letters
20
發行號3
DOIs
出版狀態已發佈 - 2010 2月 1

ASJC Scopus subject areas

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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