Synthesis and reactivity of open-chain and cyclic 2-cyano zinc and copper organometallics

Tahir N. Majid*, Ming Chang P. Yeh, Paul Knochel

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

31 引文 斯高帕斯(Scopus)

摘要

Various open-chain and cyclic β-cyano zinc and copper organometallics can be prepared by the reaction of the corresponding organic halides with zinc and subsequent transmetalation with CuCN · 2 LiCl. They react in fair to good yields with various organic electrophiles (enones, allylic bromides and benzoyl chloride) affording highly functionalized nitriles. High diastereoselectivities have been observed in coupling reactions with the cyclic 2-cyano organocopper derivatives. The x-ray structure of cyanoethylzinc iodide is also reported.

原文英語
頁(從 - 到)5069-5072
頁數4
期刊Tetrahedron Letters
30
發行號38
DOIs
出版狀態已發佈 - 1989
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 藥物發現
  • 有機化學

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