TY - JOUR
T1 - Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores
AU - Mathusalini, Sadasivam
AU - Arasakumar, Thangaraj
AU - Lakshmi, Krishnasamy
AU - Lin, Chia Her
AU - Mohan, Palathurai Subramaniam
AU - Ramnath, Madhusudhanan Gogul
AU - Thirugnanasampandan, Ramaraj
N1 - Publisher Copyright:
© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2016.
PY - 2016
Y1 - 2016
N2 - A regioselective synthesis of new mono and bisoxindoles containing bis spiro heterocyclic hybrids has been envisaged via 1,3-dipolar cycloaddition of azomethine ylides with the dipolarophile (E)-3-((2-methoxyquinolin-3-yl)methylene)indolin-2-one, obtained through the base catalyzed condensation of indolin-2-one with substituted 2-methoxyquinoline-3-carbaldehyde. The regiochemistry and stereochemistry of the synthesized products were characterized by 1D and 2D NMR techniques and single crystal X-ray diffraction studies. Many of the compounds were found to show in vitro antioxidant, antidiabetic and acetylcholinesterase inhibitory activities.
AB - A regioselective synthesis of new mono and bisoxindoles containing bis spiro heterocyclic hybrids has been envisaged via 1,3-dipolar cycloaddition of azomethine ylides with the dipolarophile (E)-3-((2-methoxyquinolin-3-yl)methylene)indolin-2-one, obtained through the base catalyzed condensation of indolin-2-one with substituted 2-methoxyquinoline-3-carbaldehyde. The regiochemistry and stereochemistry of the synthesized products were characterized by 1D and 2D NMR techniques and single crystal X-ray diffraction studies. Many of the compounds were found to show in vitro antioxidant, antidiabetic and acetylcholinesterase inhibitory activities.
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U2 - 10.1039/c6nj00534a
DO - 10.1039/c6nj00534a
M3 - Article
AN - SCOPUS:84974566686
SN - 1144-0546
VL - 40
SP - 5164
EP - 5169
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 6
ER -