Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores

Sadasivam Mathusalini, Thangaraj Arasakumar, Krishnasamy Lakshmi, Chia Her Lin, Palathurai Subramaniam Mohan*, Madhusudhanan Gogul Ramnath, Ramaraj Thirugnanasampandan

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

31 引文 斯高帕斯(Scopus)

摘要

A regioselective synthesis of new mono and bisoxindoles containing bis spiro heterocyclic hybrids has been envisaged via 1,3-dipolar cycloaddition of azomethine ylides with the dipolarophile (E)-3-((2-methoxyquinolin-3-yl)methylene)indolin-2-one, obtained through the base catalyzed condensation of indolin-2-one with substituted 2-methoxyquinoline-3-carbaldehyde. The regiochemistry and stereochemistry of the synthesized products were characterized by 1D and 2D NMR techniques and single crystal X-ray diffraction studies. Many of the compounds were found to show in vitro antioxidant, antidiabetic and acetylcholinesterase inhibitory activities.

原文英語
頁(從 - 到)5164-5169
頁數6
期刊New Journal of Chemistry
40
發行號6
DOIs
出版狀態已發佈 - 2016
對外發佈

ASJC Scopus subject areas

  • 催化
  • 化學 (全部)
  • 材料化學

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