Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores

Sadasivam Mathusalini; Thangaraj Arasakumar; Krishnasamy Lakshmi; Chia Her Lin; Palathurai Subramaniam Mohan; Madhusudhanan Gogul Ramnath; Ramaraj Thirugnanasampandan

doi:10.1039/c6nj00534a

Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores

Sadasivam Mathusalini, Thangaraj Arasakumar, Krishnasamy Lakshmi, Chia Her Lin, Palathurai Subramaniam Mohan^*, Madhusudhanan Gogul Ramnath, Ramaraj Thirugnanasampandan

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研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

31 引文斯高帕斯（Scopus）

摘要

A regioselective synthesis of new mono and bisoxindoles containing bis spiro heterocyclic hybrids has been envisaged via 1,3-dipolar cycloaddition of azomethine ylides with the dipolarophile (E)-3-((2-methoxyquinolin-3-yl)methylene)indolin-2-one, obtained through the base catalyzed condensation of indolin-2-one with substituted 2-methoxyquinoline-3-carbaldehyde. The regiochemistry and stereochemistry of the synthesized products were characterized by 1D and 2D NMR techniques and single crystal X-ray diffraction studies. Many of the compounds were found to show in vitro antioxidant, antidiabetic and acetylcholinesterase inhibitory activities.

原文	英語
頁（從 - 到）	5164-5169
頁數	6
期刊	New Journal of Chemistry
卷	40
發行號	6
DOIs	https://doi.org/10.1039/c6nj00534a
出版狀態	已發佈 - 2016
對外發佈	是

ASJC Scopus subject areas

催化
化學 (全部)
材料化學

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Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores. / Mathusalini, Sadasivam; Arasakumar, Thangaraj; Lakshmi, Krishnasamy; Lin, Chia Her; Mohan, Palathurai Subramaniam; Ramnath, Madhusudhanan Gogul; Thirugnanasampandan, Ramaraj.

於: New Journal of Chemistry, 卷 40, 編號 6, 2016, p. 5164-5169.

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

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AU - Mathusalini, Sadasivam

AU - Arasakumar, Thangaraj

AU - Lakshmi, Krishnasamy

AU - Lin, Chia Her

AU - Mohan, Palathurai Subramaniam

AU - Ramnath, Madhusudhanan Gogul

AU - Thirugnanasampandan, Ramaraj

PY - 2016

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AB - A regioselective synthesis of new mono and bisoxindoles containing bis spiro heterocyclic hybrids has been envisaged via 1,3-dipolar cycloaddition of azomethine ylides with the dipolarophile (E)-3-((2-methoxyquinolin-3-yl)methylene)indolin-2-one, obtained through the base catalyzed condensation of indolin-2-one with substituted 2-methoxyquinoline-3-carbaldehyde. The regiochemistry and stereochemistry of the synthesized products were characterized by 1D and 2D NMR techniques and single crystal X-ray diffraction studies. Many of the compounds were found to show in vitro antioxidant, antidiabetic and acetylcholinesterase inhibitory activities.

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Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores

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