Syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by Fe/HCl

Wen Chang Chen; Chan Chieh Lin; Veerababurao Kavala; Chun Wei Kuo; Chia Yu Huang; Ching Fa Yao

doi:10.3390/molecules201219862

Syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by Fe/HCl

Wen Chang Chen, Chan Chieh Lin, Veerababurao Kavala, Chun Wei Kuo, Chia Yu Huang, Ching Fa Yao^*

^*此作品的通信作者

化學系

研究成果: 雜誌貢獻 › 期刊論文 › 同行評審

4 引文斯高帕斯（Scopus）

摘要

An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high.

原文	英語
頁（從 - 到）	22499-22519
頁數	21
期刊	Molecules
卷	20
發行號	12
DOIs	https://doi.org/10.3390/molecules201219862
出版狀態	已發佈 - 2015 12月 15

ASJC Scopus subject areas

分析化學
化學（雜項）
分子醫學
藥學科學
藥物發現
物理與理論化學
有機化學

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10.3390/molecules201219862

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title = "Syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by Fe/HCl",

abstract = "An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high.",

keywords = "4-indolylquinoline, Fe/HCl, Indolylchalcone, Reductive cyclization",

author = "Chen, {Wen Chang} and Lin, {Chan Chieh} and Veerababurao Kavala and Kuo, {Chun Wei} and Huang, {Chia Yu} and Yao, {Ching Fa}",

note = "Publisher Copyright: {\textcopyright} 2015 by The Authors.",

year = "2015",

month = dec,

day = "15",

doi = "10.3390/molecules201219862",

language = "English",

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T1 - Syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by Fe/HCl

AU - Chen, Wen Chang

AU - Lin, Chan Chieh

AU - Kavala, Veerababurao

AU - Kuo, Chun Wei

AU - Huang, Chia Yu

AU - Yao, Ching Fa

PY - 2015/12/15

Y1 - 2015/12/15

N2 - An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high.

AB - An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high.

KW - 4-indolylquinoline

KW - Fe/HCl

KW - Indolylchalcone

KW - Reductive cyclization

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UR - http://www.scopus.com/inward/citedby.url?scp=84954349611&partnerID=8YFLogxK

U2 - 10.3390/molecules201219862

DO - 10.3390/molecules201219862

M3 - Article

C2 - 26694335

AN - SCOPUS:84954349611

VL - 20

SP - 22499

EP - 22519

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 12

ER -

Syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by Fe/HCl

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