Syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by Fe/HCl

Wen Chang Chen, Chan Chieh Lin, Veerababurao Kavala, Chun Wei Kuo, Chia Yu Huang, Ching Fa Yao*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

3 引文 斯高帕斯(Scopus)

摘要

An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high.

原文英語
頁(從 - 到)22499-22519
頁數21
期刊Molecules
20
發行號12
DOIs
出版狀態已發佈 - 2015 十二月 15

ASJC Scopus subject areas

  • 分析化學
  • 化學(雜項)
  • 分子醫學
  • 藥學科學
  • 藥物發現
  • 物理與理論化學
  • 有機化學

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