摘要
An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high.
原文 | 英語 |
---|---|
頁(從 - 到) | 22499-22519 |
頁數 | 21 |
期刊 | Molecules |
卷 | 20 |
發行號 | 12 |
DOIs | |
出版狀態 | 已發佈 - 2015 12月 15 |
ASJC Scopus subject areas
- 分析化學
- 化學(雜項)
- 分子醫學
- 藥學科學
- 藥物發現
- 物理與理論化學
- 有機化學