Structural Analysis of Genomic Sequences with Matched Filtering

Shih Chieh Su, Chia H. Yeh, C. C.Jay Kuo

研究成果: 雜誌貢獻會議論文同行評審

14 引文 斯高帕斯(Scopus)

摘要

A pattern filtering approach is developed to analyze genomic sequences in this work. With this approach, the distance of a certain pattern is first translated into a "gap sequence" consisting of integer numbers. Different patterns result in different gap sequences, and the similarity measure of two genomic sequences can be made based upon the processing of gap sequences generated by a set of pre-selected patterns. A matched filtering approach is applied to gap sequences. Furthermore, several post-processing techniques are applied to the filtered result for signal enhancement. For example, the modified Butterworth window (MBW) is used to remove the edge effect of the matched filter output, and the uncertain region is beleaguered by the advanced similarity test (AST) algorithm. The match between gap sequences is called a "frame match". The actual match of two genomic sequences demands both frame match and stuffing match. The proposed approach is useful for sequence analysis based on the frame match with desirable patterns. Extensive experimental results are presented to demonstrate the performance of the proposed method.

原文英語
頁(從 - 到)2893-2896
頁數4
期刊Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
3
出版狀態已發佈 - 2003
對外發佈
事件A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, 墨西哥
持續時間: 2003 9月 172003 9月 21

ASJC Scopus subject areas

  • 訊號處理
  • 生物醫學工程
  • 電腦視覺和模式識別
  • 健康資訊學

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