Stereoselective three-component synthesis of trans-endo-decahydroquinolin- 4-one derivatives from aldehydes, aniline, and acetylcyclohexene

Chunchi Lin; Hulin Fang; Zhijay Tu; Ju Tsung Liu; Ching Fa Yao

doi:10.1021/jo060992c

Stereoselective three-component synthesis of trans-endo-decahydroquinolin- 4-one derivatives from aldehydes, aniline, and acetylcyclohexene

Chunchi Lin, Hulin Fang, Zhijay Tu, Ju Tsung Liu, Ching Fa Yao

化學系

研究成果: 雜誌貢獻 › 文章 › 同行評審

35 引文斯高帕斯（Scopus）

摘要

The diastereoselective synthesis of trans-endo-decahydroquinolin-4-one (4) via a three-component reaction of aldehydes (1), anilines (2), and 1-acetylcyclohexene (3) in the presence of iodine in a one-pot reaction at room temperature is described. The short reaction time, easy workup, excellent yield, and mild reaction conditions make this novel annulation strategy both practical and attractive.

原文	英語
頁（從 - 到）	6588-6591
頁數	4
期刊	Journal of Organic Chemistry
卷	71
發行號	17
DOIs	https://doi.org/10.1021/jo060992c
出版狀態	已發佈 - 2006 八月 18

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo060992c

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引用此

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