Stereoselective Synthesis of 7-(E)-Arylidene-2-chloro-6-azabicyclo[3.2.1]octanes via Aluminum Chloride-Promoted Cyclization/Chlorination of Six-Membered Ring 3-Enynamides

Ming-Chang P. Yeh, Yi Mei Chang, Hsin Hui Lin

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

An efficient stereoselective synthesis of 7-(E)-arylidene-2-chloro-6-azabicyclo[3.2.1]octanes is described. The aluminum chloride-promoted cyclization/chlorination of six-membered ring 3-enynamides enables a straightforward approach to the 6-azabicyclo[3.2.1]octane nucleus that is incorporated in many biologically active compounds. Acid treatment of the resultant chlorinated arylideneazabicyclooctanes furnishes 3-alkanoyl-4-chlorocyclohexanamines in excellent yields and high stereoselectivity. (Figure presented.).

原文英語
頁(從 - 到)2196-2201
頁數6
期刊Advanced Synthesis and Catalysis
359
發行號13
DOIs
出版狀態已發佈 - 2017 一月 1

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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