Statins Improve Long Term Patency of Arteriovenous Fistula for Hemodialysis

Hao Hsiang Chang, Yu Kang Chang, Chia Wen Lu, Chi Ting Huang, Chiang Ting Chien, Kuan Yu Hung, Kuo Chin Huang, Chih Cheng Hsu

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

摘要

The protective effects of statins against stenosis for permanent hemodialysis access have been repeatedly demonstrated in animal studies, but remain controversial in human studies. This study aims to evaluate the association between statin use and permanent hemodialysis access patency using a nationwide hemodialysis cohort. A total of 9862 pairs of statin users and non-users, matched by age and gender, were selected for investigation from 75404 new hemodialysis patients during 2000-2008. The effect of statins on permanent hemodialysis access patency was evaluated using Cox proportional hazards models. Compared with non-users, statin users had an overall 18% risk reduction in the composite endpoint in which angioplasty and recreation were combined (adjusted hazard ratio = 0.82 [95%CI, 0.78-0.87]) and 21% in recreation of permanent hemodialysis access (adjusted hazard ratio = 0.79 [95%CI, 0.69-0.80]). Specifically, the protective effect was found for arteriovenous fistula (adjusted hazard ratio = 0.78[95% CI, 0.73-0.82] for composite endpoint and 0.74 [95% CI, 0.69-0.80] for vascular recreation), but not for arteriovenous grafts (adjusted hazard ratio = 1.10 [95% CI, 0.98-1.24] and 0.94 [95% CI, 0.83-1.07]). Statins possess a protective effect for arteriovenous fistula against the recreation of permanent hemodialysis access. The results provide a pharmaco-epidemiologic link between basic research and clinical evidence.

原文英語
文章編號22197
期刊Scientific Reports
6
DOIs
出版狀態已發佈 - 2016 二月 23

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ASJC Scopus subject areas

  • General

引用此

Chang, H. H., Chang, Y. K., Lu, C. W., Huang, C. T., Chien, C. T., Hung, K. Y., Huang, K. C., & Hsu, C. C. (2016). Statins Improve Long Term Patency of Arteriovenous Fistula for Hemodialysis. Scientific Reports, 6, [22197]. https://doi.org/10.1038/srep22197