Splenectomy in trauma patients is associated with an increased risk of postoperative type II diabetes: A nationwide population-based study

Shih Chi Wu, Chih Yuan Fu, Chih Hsin Muo, Yen Jung Chang*

*此作品的通信作者

研究成果: 雜誌貢獻期刊論文同行評審

16 引文 斯高帕斯(Scopus)

摘要

Background Animal studies indicate that splenocytes may act as precursors of β-islet secretory cells in the pancreas. This study aimed to assess the risk of postoperative type II diabetes after splenectomy in trauma patients.

Methods We used data from the Taiwan National Health Insurance hospitalized claims. Study 1 included 3,723 patients receiving splenectomy and 3,723 matched patients receiving other types of abdominal surgery. Study 2 included 5,996 patients with spleen injury and 5,996 matched patients with other types of abdominal injury. The hazard ratio for diabetes was estimated using the matched Cox proportional hazard regression model.

Results In trauma patients after surgery, those who received splenectomy had a 2-fold higher risk of diabetes compared with patients without splenectomy after a 3-year follow-up period. In the nonoperative group, there was no difference in diabetes risk between patients with splenic injury and those with other types of injury.

Conclusions Splenectomy was associated with an increased risk of postoperative type II diabetes in trauma patients. Thus, there may be a role for the spleen in the development of diabetes.

原文英語
頁(從 - 到)811-816
頁數6
期刊American Journal of Surgery
208
發行號5
DOIs
出版狀態已發佈 - 2014 十一月 1

ASJC Scopus subject areas

  • 手術

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