TY - JOUR
T1 - Splenectomy in trauma patients is associated with an increased risk of postoperative type II diabetes
T2 - A nationwide population-based study
AU - Wu, Shih Chi
AU - Fu, Chih Yuan
AU - Muo, Chih Hsin
AU - Chang, Yen Jung
N1 - Funding Information:
Supported by the Taiwan Department of Health Clinical Trial and Research Center for Excellence ( DOH102-TD-B-111-004 ) and the Taiwan Department of Health Cancer Research Center for Excellence ( DOH102-TD-C-111-005 ).
Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Background Animal studies indicate that splenocytes may act as precursors of β-islet secretory cells in the pancreas. This study aimed to assess the risk of postoperative type II diabetes after splenectomy in trauma patients.Methods We used data from the Taiwan National Health Insurance hospitalized claims. Study 1 included 3,723 patients receiving splenectomy and 3,723 matched patients receiving other types of abdominal surgery. Study 2 included 5,996 patients with spleen injury and 5,996 matched patients with other types of abdominal injury. The hazard ratio for diabetes was estimated using the matched Cox proportional hazard regression model.Results In trauma patients after surgery, those who received splenectomy had a 2-fold higher risk of diabetes compared with patients without splenectomy after a 3-year follow-up period. In the nonoperative group, there was no difference in diabetes risk between patients with splenic injury and those with other types of injury.Conclusions Splenectomy was associated with an increased risk of postoperative type II diabetes in trauma patients. Thus, there may be a role for the spleen in the development of diabetes.
AB - Background Animal studies indicate that splenocytes may act as precursors of β-islet secretory cells in the pancreas. This study aimed to assess the risk of postoperative type II diabetes after splenectomy in trauma patients.Methods We used data from the Taiwan National Health Insurance hospitalized claims. Study 1 included 3,723 patients receiving splenectomy and 3,723 matched patients receiving other types of abdominal surgery. Study 2 included 5,996 patients with spleen injury and 5,996 matched patients with other types of abdominal injury. The hazard ratio for diabetes was estimated using the matched Cox proportional hazard regression model.Results In trauma patients after surgery, those who received splenectomy had a 2-fold higher risk of diabetes compared with patients without splenectomy after a 3-year follow-up period. In the nonoperative group, there was no difference in diabetes risk between patients with splenic injury and those with other types of injury.Conclusions Splenectomy was associated with an increased risk of postoperative type II diabetes in trauma patients. Thus, there may be a role for the spleen in the development of diabetes.
KW - Postoperative diabetes
KW - Splenectomy
KW - Trauma
UR - http://www.scopus.com/inward/record.url?scp=84911430235&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84911430235&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2014.03.003
DO - 10.1016/j.amjsurg.2014.03.003
M3 - Article
C2 - 24928333
AN - SCOPUS:84911430235
SN - 0002-9610
VL - 208
SP - 811
EP - 816
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 5
ER -
