Soybean Peptide Lunasin Suppresses In Vitro and In Vivo 7,12-Dimethylbenz[a]anthracene-Induced Tumorigenesis

Chia Chien Hsieh, Blanca Hernández-Ledesma, Ben O. De Lumen

研究成果: 雜誌貢獻文章

38 引文 斯高帕斯(Scopus)

摘要

Abstract: Lunasin is a novel peptide identified in soybean and other seeds. This study evaluated the anti-tumorigenic effects of lunasin on 7,12-dimethylbenz(a)anthracene (DMBA) and 3-methylcholanthrene-treated (MCA) fibroblast NIH/3T3 cells. Lunasin significantly inhibited cell proliferation and cancerous foci formation in these 2 chemical carcinogens-treated cells. An in vivo SENCAR mouse model induced with DMBA was used to study the mammary cancer preventive properties of dietary lunasin contained in soy protein. Tumor incidence was 67% and 50%, and the tumor generation was 1.88 ± 0.48 and 1.17 ± 0.17, respectively, for the mice fed control diet and experimental diet obtained after AIN-93G supplementation with lunasin-enriched soy protein concentrate (containing 0.23% lunasin). However, no effects were observed in mice fed AIN-93G supplemented with soy protein concentrate (containing 0.15% lunasin). The data provided illustrate the anticancer potential of lunasin both in vitro and in vivo and supports the recommendation of soy protein as a dietary component that may aid in the prevention of mammary cancer.Practical Application: Daily intake of lunasin-enriched soy protein is introduced as a promising strategy to prevent chemical carcinogens-induced mammary tumors.

原文英語
頁(從 - 到)H311-H316
期刊Journal of Food Science
75
發行號9
DOIs
出版狀態已發佈 - 2010 十一月 1
對外發佈Yes

ASJC Scopus subject areas

  • Food Science

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